AKR1C1 - aldo-keto reductase family 1 member C1 Gene

Also Known as C9; DD1; DDH; DDH1; H-37; HBAB; MBAB; HAKRC; DD1/DD2; 2-ALPHA-HSD; 20-ALPHA-HSD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1645

About AKR1C1

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:4,963,415-4,983,283 (from NCBI)

This gene has 5 transcripts (splice variants), 491 orthologues and 16 paralogues. Biased expression in liver (RPKM 85.2), fat (RPKM 74.3) and 13 other tissues.

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. These Enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The Enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three Other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

AKR1C1 Products (1)

mRNA Protein Name
NM_001353.6 NP_001344.2 aldo-keto reductase family 1 member C1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables aldose reductase (NADPH) activity IDA
IDA: Inferred from direct assay
21232532 GOA
enables androsterone dehydrogenase (B-specific) activity IDA
IDA: Inferred from direct assay
8486699 GOA
enables bile acid binding IDA
IDA: Inferred from direct assay
8486699 GOA
enables carboxylic acid binding IDA
IDA: Inferred from direct assay
8486699 GOA
enables ketosteroid monooxygenase activity IDA
IDA: Inferred from direct assay
21232532 GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
IDA: Inferred from direct assay
19442656 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity IDA
IDA: Inferred from direct assay
8486699 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in bile acid metabolic process IDA
IDA: Inferred from direct assay
8486699 GOA
involved in cellular response to jasmonic acid stimulus IDA
IDA: Inferred from direct assay
19487289 GOA
involved in daunorubicin metabolic process IMP
IMP: Inferred from mutant phenotype
20837989 GOA
involved in digestion IDA
IDA: Inferred from direct assay
8486699 GOA
involved in doxorubicin metabolic process IMP
IMP: Inferred from mutant phenotype
20837989 GOA
involved in epithelial cell differentiation IDA
IDA: Inferred from direct assay
21492153 GOA
involved in positive regulation of reactive oxygen species metabolic process IDA
IDA: Inferred from direct assay
19442656 GOA
involved in progesterone metabolic process IDA
IDA: Inferred from direct assay
21232532 GOA
involved in response to organophosphorus IEP
IEP: Inferred from expression pattern
16079077 GOA
involved in retinal metabolic process IDA
IDA: Inferred from direct assay
21851338 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytosol IDA
IDA: Inferred from direct assay
8486699 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR1C1 Protein Structure

Aldo_ket_red

Aldo_ket_red: Aldo/keto reductase family (19 - 300)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
Protein Preferred Names Protein Names

aldo-keto reductase family 1 member C1

  • 20 alpha-hydroxysteroid dehydrogenase

AKR1C1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
AKR1C1 Q04828 PTPN3 Homo sapiens P26045
Y2H Prey Pooling
32296183
Intra
AKR1C1 Q04828 PTPN3 Homo sapiens P26045
Validated Y2H
25416956
Intra
AKR1C1 Q04828 PTPN3 Homo sapiens P26045
Y2H Array
25416956
Intra
AKR1C1 Q04828 AKR1D1 Homo sapiens P51857
Anti Tag CoIP
33961781
Intra
AKR1C1 Q04828 AKR1D1 Homo sapiens P51857
Anti Tag CoIP
28514442
Intra
AKR1C1 Q04828 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
AKR1C1 Q04828 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
AKR1C1 Q04828 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

AKR1C1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82930 AKR1C1/AKR1C2 Antibody (YA2675) WB, FC Human, Mouse, Rat
HY-P84483 AKR1C1 Antibody (YA4180) WB, IHC-P, FC Human, Mouse, Rabbit
HY-P84483A AKR1C1 Antibody (YA4180)(PBS only) WB, IHC-P, FC Human, Mouse, Rabbit
HY-P87505 AKR1C1 Antibody (YA7189) WB, IHC-P Human, Mouse

Related Diseases

Diseases Alias
Developmental Dysplasia Of The Hip 1

  • Acetabular Dysplasia

  • Developmental Dysplasia Of The Hip

  • DDH1

  • Hip Dysplasia, Developmental

  • Ddh

  • Hip Dysplasia, Congenital

  • Cdh

  • Congenital Hip Dislocation Nos
Lipedema
Endometrial Cancer

  • Endometrial Carcinoma

  • Endometrial Neoplasm

  • Malignant Neoplasm Of Endometrium

  • Endometrioid Carcinoma

  • Endometrial Neoplasms

  • Carcinoma, Endometrioid

  • Endometrial Cancer, Familial

  • Endometrial Carcinoma, Somatic

  • Endometrial Cancer, Susceptibility To

  • Endometrial Ca

  • Malignant Endometrial Neoplasm

  • Neoplasm Of Endometrium

  • Primary Malignant Neoplasm Of Endometrium

  • Tumor Of Endometrium

  • Carcinoma Of The Endometrium

  • Endometrioid Carcinoma Of Female Reproductive System

  • ENDMC

  • Carcinoma Endometrioid

  • Endometrial Cancers

  • Cancer, Endometrial

  • Uterine Corpus Cancer
Lung Benign Neoplasm

  • Lung Neoplasms

  • Tumor Of The Lung

  • Lung Tumor
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Pituitary Adenoma 2, Growth Hormone-Secreting

  • PITA2

  • Acromegaly Due To Pituitary Adenoma 2

  • Acromegaly, X-Linked

  • Growth Hormone Secreting Pituitary Adenoma 2

  • Pituitary Adenoma, Growth Hormone-Secreting, 2

  • Pituitary Adenoma 2, Gh-Secreting

  • Gh-Secreting Pituitary Adenoma 2

  • X-Linked Acromegaly

  • Adenoma, Pituitary, Growth Hormone-Secreting, Type 2
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-114009 AKR1C1-IN-1 Inhibitor 99.87% Unkown
HY-118819 5-Bromo-3-phenyl salicylic acid Inhibitor 98.00% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AKR1C1 RGD RGD:1306847