H1-7 - H1.7 linker histone Gene

Also Known as H1.7; H1T2; H1FNT

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 341567

About H1-7

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:48,328,980-48,330,279 (from NCBI)

This gene has 1 transcript (splice variant), 53 orthologues and 9 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. The related mouse gene encodes a testis specific protein that is required for spermatogenesis and male fertility. [provided by RefSeq, Oct 2015]

H1-7 Products (1)

mRNA Protein Name
NM_181788.1 NP_861453.1 testis-specific H1 histone

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

testis-specific H1 histone

  • H1 histone family member N, testis specific

H1-7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
H1-7 Q75WM6 H2BC15 Homo sapiens U3KQK0
Validated Y2H
32296183
Intra
H1-7 Q75WM6 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
H1-7 Q75WM6 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-113238A Lithocholic acid 3-sulfate disodium 99.93% Unkown
HY-137255 Taurolithocholic acid 3-sulfate disodium Agonist 99.9% Unkown
HY-W587430 Glycolithocholic acid 3-sulfate disodium 99.73% Unkown
HY-P3745 H1-7 (histone H1 phosphorylation site), PKA Substrate / Unkown
HY-RS05080 FOXRED1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05952 H1-7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179252 PMK1-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus H1-7 MGD MGI:1917319
Rattus norvegicus H1-7 RGD RGD:1560024
Macaca mulatta H1-7 VGNC VGNC:109747
Canis familiaris H1-7 VGNC VGNC:83735
Others H1-7 NCBI