PLK2 - polo like kinase 2 Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 478063

About PLK2

Primary_assembly 2: 45,844,939-45,850,697 reverse strand.ROS_Cfam_1.0:CM025101.1

This gene has 2 transcripts (splice variants), 221 orthologues and 4 paralogues.

PLK2 Products (1)

mRNA Protein Name
XM_038658935.1 XP_038514863.1 serine/threonine-protein kinase PLK2

PLK2 Protein Structure

STKc_PLK2

STKc_PLK2: cd14188 (80 - 334)

POLO_box_1

POLO_box_1: cd13118 (503 - 588)

POLO_box_2

POLO_box_2: cd13117 (601 - 682)

  • 0
  • 200
  • 400
  • 600
  • 686 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12137 Volasertib Inhibitor 99.97% Yes
HY-12137A Volasertib trihydrochloride Inhibitor 99.12% Yes

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-12037 Rigosertib sodium Inhibitor 99.57% Phase 3
HY-50698 BI 2536 Inhibitor 99.95% Phase 2
HY-147298 Plogosertib Inhibitor 98.59% Phase 2
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-15160B TAK-960 dihydrochloride Inhibitor 99.15% Phase 1
HY-15160A TAK-960 hydrochloride Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12037A Rigosertib Inhibitor 99.01% Unkown
HY-100789 ON1231320 Inhibitor 99.90% Unkown
HY-12134 Poloxin Inhibitor 98.05% Unkown
HY-108597 TC-S 7005 Inhibitor 99.68% Unkown
HY-180896 8012–3246 Inhibitor 99.72% Unkown
HY-173212 PLK1-IN-13 Inhibitor / Unkown
HY-149100 PLK1-IN-6 Inhibitor / Unkown
HY-172364 PLK1-IN-12 Inhibitor / Unkown
HY-115589 YLT-11 Inhibitor / Unkown
HY-181030 BDE30671203 Inhibitor / Unkown
HY-181051 PLK1-IN-16 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PLK2 NCBI NCBI:10769