Ramp2 - receptor (calcitonin) activity modifying protein 2 Gene

Mus musculus

Gene ID: 54409 | Gene type: protein coding

About Ramp2

Summary

Enables coreceptor activity. Involved in several processes, including cell-cell junction assembly; circulatory system development; and negative regulation of endothelial cell apoptotic process. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of Adrenomedullin receptor complex and Amylin Receptor complex 2. Predicted to be active in cell surface. Predicted to colocalize with plasma membrane. Is expressed in several structures, including cardiovascular system; forelimb bud; gut; liver; and prostate gland lobe. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RAMP2 (receptor activity modifying protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Ramp2 Products(1)

mRNA	Protein	Name
NM_019444.2	NP_062317.1	receptor activity-modifying protein 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables coreceptor activity	IDA IDA: Inferred from direct assay	10854696	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IPI IPI: Inferred from physical interaction	10854696	MGI
involved in adherens junction assembly	IMP IMP: Inferred from mutant phenotype	18097473	MGI
involved in basement membrane assembly	IMP IMP: Inferred from mutant phenotype	18097473	MGI
involved in bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	18097473	MGI
involved in cellular response to vascular endothelial growth factor stimulus	IMP IMP: Inferred from mutant phenotype	18097473	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	18097473	MGI
involved in negative regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	18097473	MGI
involved in negative regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	18097473	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	18097473	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18097473	MGI
involved in positive regulation of vasculogenesis	IMP IMP: Inferred from mutant phenotype	18097473	MGI
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	18097473	MGI
involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	18097473	MGI
involved in vascular associated smooth muscle cell development	IMP IMP: Inferred from mutant phenotype	18097473	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

receptor activity-modifying protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1548	β-CGRP, human		99.36%	Unkown
HY-P1548A	β-CGRP, human TFA		99.57%	Unkown
HY-P1548B	β-CGRP, human acetate		/	Unkown
HY-RS11639	RAMP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183142	CLR/RAMP3-receptor antagonist-1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ramp2	NCBI	NCBI:10266

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