Ramp2 - receptor (calcitonin) activity modifying protein 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54409

Summary

Enables coreceptor activity. Involved in several processes, including cell-cell junction assembly; circulatory system development; and negative regulation of endothelial cell apoptotic process. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of Adrenomedullin receptor complex and Amylin Receptor complex 2. Predicted to be active in cell surface. Predicted to colocalize with plasma membrane. Is expressed in several structures, including cardiovascular system; forelimb bud; gut; liver; and prostate gland lobe. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RAMP2 (receptor activity modifying protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Ramp2 Products (1)

mRNA Protein Name
NM_019444.2 NP_062317.1 receptor activity-modifying protein 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables coreceptor activity IDA
IDA: Inferred from direct assay
10854696 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IPI
IPI: Inferred from physical interaction
10854696 MGI
involved in adherens junction assembly IMP
IMP: Inferred from mutant phenotype
18097473 MGI
involved in basement membrane assembly IMP
IMP: Inferred from mutant phenotype
18097473 MGI
involved in bicellular tight junction assembly IMP
IMP: Inferred from mutant phenotype
18097473 MGI
involved in cellular response to vascular endothelial growth factor stimulus IMP
IMP: Inferred from mutant phenotype
18097473 MGI
involved in heart development IMP
IMP: Inferred from mutant phenotype
18097473 MGI
involved in negative regulation of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
18097473 MGI
involved in negative regulation of vascular permeability IMP
IMP: Inferred from mutant phenotype
18097473 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
18097473 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18097473 MGI
involved in positive regulation of vasculogenesis IMP
IMP: Inferred from mutant phenotype
18097473 MGI
involved in regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
18097473 MGI
involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
18097473 MGI
involved in vascular associated smooth muscle cell development IMP
IMP: Inferred from mutant phenotype
18097473 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor activity-modifying protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1548 β-CGRP, human 99.36% Unkown
HY-P1548A β-CGRP, human TFA 99.57% Unkown
HY-P1548B β-CGRP, human acetate / Unkown
HY-RS11639 RAMP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183142 CLR/RAMP3-receptor antagonist-1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ramp2 NCBI NCBI:10266