RAMP2 - receptor activity modifying protein 2 Gene

Homo sapiens

Gene ID: 10266 | Gene type: protein coding

About RAMP2

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,761,227-42,763,041 (from NCBI)

This gene has 6 transcripts (splice variants), 198 orthologues and 2 paralogues. Broad expression in lung (RPKM 58.9), fat (RPKM 57.7) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (Calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an Adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an Adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of Adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]

RAMP2 Products(1)

mRNA	Protein	Name
NM_005854.3	NP_005845.2	receptor activity-modifying protein 2 precursor

RAMP2 Protein Structure

RAMP

0
100
175 a.a.

Protein Preferred Names

Protein Names

receptor activity-modifying protein 2

CRLR activity-modifying protein 2

Related Diseases

Diseases

Alias

Pheochromocytoma

Pheochromocytoma, Susceptibility To	Phaeochromocytoma
Adrenal Gland Chromaffin Paraganglioma	Adrenal Gland Chromaffinoma
Adrenal Gland Paraganglioma	Adrenal Gland Pheochromocytoma
Chromaffin Paraganglioma Of The Adrenal Gland	Intraadrenal Paraganglioma
PCC	Chromaffin Cell Tumor
Medullary Chromaffinoma	Medullary Paraganglioma
Pheochromoblastoma	Pheochromocytomas
Chromaffin Cell Neoplasm	Pheochromocytoma, Malignant

Cartilage Cancer

Chondrogenic Neoplasm

Lutembacher'S Syndrome

Lutembacher Syndrome

Lutembacher'S Anomaly

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-P1548A	β-CGRP, human TFA	99.42%	Unkown
HY-P1548	β-CGRP, human	/	Unkown
HY-P1548B	β-CGRP, human acetate	/	Unkown
HY-RS11639	RAMP2 Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RAMP2	VGNC	VGNC:69231
Macaca mulatta	RAMP2	VGNC	VGNC:76653
Mus musculus	RAMP2	MGD	MGI:1859650
Bos taurus	RAMP2	VGNC	VGNC:33707
Rattus norvegicus	RAMP2	RGD	RGD:61872

Name
Email *

	Sorry, but the email address you supplied was invalid.