2. Gene
  3. CALCRL - calcitonin receptor like receptor Gene

CALCRL - calcitonin receptor like receptor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CRLR; CGRPR; LMPHM8

Gene ID: 10203 | Gene type: protein coding

About CALCRL

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:187,341,964-187,448,252 (from NCBI)

This gene has 9 transcripts (splice variants), 148 orthologues, 42 paralogues and is associated with 1 phenotype. Broad expression in lung (RPKM 41.7), fat (RPKM 35.2) and 20 other tissues.

Summary

Enables Adrenomedullin binding activity; Adrenomedullin receptor activity; and Calcitonin gene-related peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to sucrose stimulus; and receptor internalization. Located in endoplasmic reticulum; endosome; and lysosome. Part of CGRP Receptor complex and Adrenomedullin receptor complex. Colocalizes with plasma membrane. Implicated in hereditary lymphedema. [provided by Alliance of Genome Resources, Apr 2022]

CALCRL Products(4)

mRNA Protein Name
NM_001271751.2 NP_001258680.1 calcitonin gene-related peptide type 1 receptor precursor
NM_001369434.1 NP_001356363.1 calcitonin gene-related peptide type 1 receptor precursor
NM_001369435.1 NP_001356364.1 calcitonin gene-related peptide type 1 receptor precursor
NM_005795.6 NP_005786.1 calcitonin gene-related peptide type 1 receptor precursor

CALCRL Protein Structure

HRM

HRM: Hormone receptor domain (63 - 129)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (140 - 380)

  • 0
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  • 400
  • 461 a.a.
Protein Preferred Names Protein Names

calcitonin gene-related peptide type 1 receptor

CGRP type 1 receptor

Related Diseases

Diseases Alias
Lymphatic Malformation 8

LMPHM8
Hereditary Lymphedema

Milroy Disease
Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant
Immune Hydrops Fetalis

Ihf

Immune Hf

Immune Fetal Edema

Immune Fetal Hydrops
Primary Lymphedema

Lymphedema Primary
Acute Closed-Angle Glaucoma

Acute Angle-Closure Glaucoma
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
Leopard Syndrome 2

LPRD2

Noonan Syndrome With Multiple Lentigines 2

Leopard Syndrome, Type 2
Cartilage Cancer

Chondrogenic Neoplasm
Hypotrichosis-Lymphedema-Telangiectasia Syndrome

HLTS

Hypotrichosis Lymphedema Telangiectasia Syndrome

Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Lutembacher'S Syndrome

Lutembacher Syndrome

Lutembacher'S Anomaly
Asperger Syndrome

Asperger Disorder

Asperger Syndrome, Susceptibility To
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01835 CALCRL Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CALCRL MGD MGI:1926944
Rattus norvegicus CALCRL RGD RGD:2255
Canis familiaris CALCRL VGNC VGNC:38665
Felis catus CALCRL VGNC VGNC:107492
Bos taurus CALCRL VGNC VGNC:26705
Macaca mulatta CALCRL VGNC VGNC:70573