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UGT1A9 - UDP glucuronosyltransferase family 1 member A9 Gene

Also Known as LUGP4; UDPGT; UGT1I; HLUGP4; UGT-1I; UGT1-9; UGT1.9; UGT1AI; UGT1-09; UGT1A9S; UDPGT 1-9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54600

About UGT1A9

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,671,898-233,773,300 (from NCBI)

This gene has 1 transcript (splice variant), 1221 orthologues and 21 paralogues.

Summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as Steroids, bilirubin, Hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on Phenols. [provided by RefSeq, Jul 2008]

UGT1A9 Products (1)

mRNA	Protein	Name
NM_021027.3	NP_066307.1	UDP-glucuronosyltransferase 1A9 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	17179145	GOA
enables enzyme inhibitor activity	IDA IDA: Inferred from direct assay	20610558	GOA
enables enzyme inhibitor activity	IGI IGI: Inferred from genetic interaction	20610558	GOA
enables glucuronosyltransferase activity	IDA IDA: Inferred from direct assay	18052087	GOA
NOT enables glucuronosyltransferase activity	IGI IGI: Inferred from genetic interaction	20610558	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	27025983	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20610558	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	20610558	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17179145	GOA
enables retinoic acid binding	IDA IDA: Inferred from direct assay	20308471	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular glucuronidation	IDA IDA: Inferred from direct assay	22579593	GOA
involved in flavone metabolic process	IDA IDA: Inferred from direct assay	18052087	GOA
involved in flavonoid glucuronidation	IDA IDA: Inferred from direct assay	20056724	GOA
involved in negative regulation of cellular glucuronidation	IDA IDA: Inferred from direct assay	18004212	GOA
involved in negative regulation of fatty acid metabolic process	IDA IDA: Inferred from direct assay	20610558	GOA
involved in xenobiotic glucuronidation	IDA IDA: Inferred from direct assay	20056724	GOA
NOT involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	20610558	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	1910331	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17179145	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UGT1A9 Protein Structure

UDPGT

0
100
200
300
400
500
530 a.a.

Protein Preferred Names	Protein Names
UDP-glucuronosyltransferase 1A9	UDP glucuronosyltransferase 1 family, polypeptide A9

Related Diseases

Diseases	Alias
Crigler-Najjar Syndrome, Type Ii	Crigler-Najjar Syndrome Type 2 Hyperbilirubinemia, Crigler-Najjar Type Ii Hblrcn2 Arias Syndrome Crigler Najjar Syndrome Type 2 Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 2 Bilirubin-Ugt Deficiency Type 2 Crigler-Najjar Syndrome 2 CN2 Cn-Ii Crigler-Najjar Syndrome Type Ii Crigler Najjar Syndrome, Type 2
Gilbert Syndrome	Gilbert Disease Gilbert'S Disease Gilbert'S Syndrome Cholemia, Familial Familial Nonhemolytic Jaundice Meulengracht Syndrome Gilbert Syndrome, Susceptibility To Hyperbilirubinemia, Gilbert Type Hblrg Hyperbilirubinemia, Arias Type Hyperbilirubinemia I Constitutional Hyperbilirubinemia Gilbert-Meulengracht Syndrome Hereditary Nonhemolytic Jaundice Hyperbilirubinemia Arias Type Hyperbilirubinemia Type 1 Constitutional Liver Dysfunction Gilbert-Lereboullet Syndrome Hyperbilirubinemia 1 Unconjugated Benign Bilirubinemia GILBS Gilberts Syndrome Familial Nonhaemolytic Jaundice Constitutional Hyperbilirubinaemia Hereditary Nonhaemolytic Bilirubinaemia Familial Nonhaemolytic Bilirubinaemia Idiopathic Hyperbilirubinaemia Icterus Intermittens Juvenilis Chronic Intermittent Juvenile Jaundice Low-Grade Chronic Hyperbilirubinaemia Syndrome Benign Unconjugated Bilirubinaemia Syndrome Hereditary Nonhaemolytic Jaundice Idiopathic Unconjugated Hyperbilirubinaemia Gilbert--Lereboullet Syndrome Constitutional Hepatic Dysfunction Meulengracht Icterus Cholaemia Familiaris Simplex Familial Cholaemia Congenital Familial Cholaemia Physiologic Cholaemia Hyperbilirubinaemia Type 1 Gilbert Cholaemia
Crigler-Najjar Syndrome, Type I	Crigler-Najjar Syndrome Crigler-Najjar Syndrome Type 1 Bilirubin Udp Glucuronyl Transferase Deficiency Crigler Najjar Syndrome Crigler Najjar Syndrome, Type 1 Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Bilirubin-Ugt Deficiency Hyperbilirubinemia, Crigler-Najjar Type I Hblrcn1 Familial Nonhemolytic Unconjugated Hyperbilirubinemia Hereditary Unconjugated Hyperbilirubinemia Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1 Bilirubin-Ugt Deficiency Type 1 Crigler-Najjar Syndrome 1 CN1 Cn-I Crigler-Najjar Syndrome Type I Hereditary Unconjugated Hyperbilirubinaemia Ugt Deficiency Bilirubin Glucuronosyltransferase Deficiency Crigler-Najjar Disease Or Syndrome Deficiency Of Glucuronosyltransferase Glucuronyl Transferase Deficiency Glucuronyltransferase Deficiency Udp Glucuronyl Transferase Deficiency Cns - [Crigler-Najjar Syndrome] Congenital Familial Nonhemolytic Jaundice
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Bilirubin, Serum Level Of, Quantitative Trait Locus 1	Bilirubin, Serum Level Of, Qtl1 BILIQTL1 Bilirubin, Serum Level Of, Quantitative Trait Locus, Type 1
Hyperbilirubinemia, Transient Familial Neonatal	Lucey-Driscoll Syndrome Transient Familial Neonatal Hyperbilirubinemia HBLRTFN Hyperbilirubinemia, Familial Transient Neonatal Hyperbilirubinemia Transient Familial Neonatal Transient Familial Hyperbilirubinemia
Kernicterus	Bilirubin Encephalopathy Hyperbilirubinemic Encephalopathy Kernicterus Spectrum Disorder
Acetaminophen Metabolism
Lennox-Gastaut Syndrome	Lennox Syndrome Encephalopathy Of Childhood Epileptic Encephalopathy Lennox-Gastaut Type Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves Lgs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0762	Isobavachin		99.88%	Unkown
HY-N4194	Glabrone	Inhibitor	99.08%	Unkown
HY-125156	Dapagliflozin-3-O-β-D-glucuronide		99.0%	Unkown
HY-135541	Darexaban maleate		/	Unkown
HY-E72111	Human UGT1A9		/	Unkown
HY-RS15433	UGT1A9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-172338	Chlorzoxazone-N-glucuronide		/	Unkown
HY-W278777	Monohexyl phthalate	Inhibitor	98.81%	Unkown
HY-W739842	8-Hydroxywarfarin	Inhibitor	95.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UGT1A9	RGD	RGD:1549771