Human UGT1A9
Human UGT1A9 is a UDP-glucuronosyltransferase. UGT1A9 catalyzes the transfer of glucuronic acid from UDP-glucuronic acid (HY-N7033) to Umbelliferone (HY-N0573), 4-methylumbelliferone (HY-N0187), Scopoletin (HY-N0342), and α-Naphthol. Functional folding of UGT1A9 requires N-glycosylation; the deglycosylated mature protein still retains full activity.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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UGT1A9 |
After purification, human UGT1A9 shows increased apparent Km values for Scopoletin (HY-N0342) and UDP-GA, while retaining high specific activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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SMILES
[Human UGT1A9]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kurkela M, et al. Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme. J Biol Chem. 2003 Feb 7;278(6):3536-44. [Content Brief]
[2]. Albert C, et al. The monkey and human uridine diphosphate-glucuronosyltransferase UGT1A9, expressed in steroid target tissues, are estrogen-conjugating enzymes. Endocrinology. 1999 Jul;140(7):3292-302. [Content Brief]
[3]. Nakajima M, et al. N-Glycosylation plays a role in protein folding of human UGT1A9. Biochemical pharmacology. 2010 Apr 15;79(8):1165-72. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Human UGT1A9 Related Classifications
HY-E72111 Related Classifications
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