Ankrd2 - ankyrin repeat domain 2 (stretch responsive muscle) Gene

Also Known as Arpp

Species: Mus musculus

Gene Type: protein coding

Gene ID: 56642

Summary

Enables chromatin binding activity; protein kinase B binding activity; and titin binding activity. Involved in negative regulation of myoblast differentiation. Acts upstream of or within several processes, including negative regulation of myotube differentiation; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and skeletal muscle cell differentiation. Located in several cellular components, including PML body; euchromatin; and sarcomere. Colocalizes with I band. Is expressed in skeletal musculature; somite; and tongue. Orthologous to human ANKRD2 (ankyrin repeat domain 2). [provided by Alliance of Genome Resources, Apr 2022]

Ankrd2 Products (1)

mRNA	Protein	Name
NM_020033.2	NP_064417.2	ankyrin repeat domain-containing protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	24434510	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23824195	MGI
enables protein kinase B binding	IPI IPI: Inferred from physical interaction	21737686	MGI
enables titin binding	IPI IPI: Inferred from physical interaction	18310072	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of myotube differentiation	IDA IDA: Inferred from direct assay	18302940	MGI
acts upstream of myotube differentiation	IMP IMP: Inferred from mutant phenotype	23824195	MGI
involved in negative regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	21737686	MGI
acts upstream of or within negative regulation of myotube differentiation	IDA IDA: Inferred from direct assay	18302940	MGI
acts upstream of or within negative regulation of myotube differentiation	IMP IMP: Inferred from mutant phenotype	23824195	MGI
acts upstream of or within regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	24434510	MGI
acts upstream of or within regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IDA IDA: Inferred from direct assay	18302940	MGI
acts upstream of or within regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	18302940	MGI
acts upstream of or within regulation of myoblast proliferation	IDA IDA: Inferred from direct assay	18302940	MGI
acts upstream of or within regulation of myoblast proliferation	IMP IMP: Inferred from mutant phenotype	18302940	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with I band	IDA IDA: Inferred from direct assay	17926058	MGI
located in I band	IDA IDA: Inferred from direct assay	14741210	MGI
located in PML body	IDA IDA: Inferred from direct assay	24434510	MGI
located in cytosol	IDA IDA: Inferred from direct assay	21737686	MGI
located in euchromatin	IDA IDA: Inferred from direct assay	17926058	MGI
located in myofibril	IDA IDA: Inferred from direct assay	18310072	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18302940	MGI
located in sarcomere	IDA IDA: Inferred from direct assay	12004005	MGI
located in sarcoplasm	IDA IDA: Inferred from direct assay	18302940	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ankyrin repeat domain-containing protein 2	skeletal muscle ankyrin repeat protein

Ankrd2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Ankrd2	Q9WV06	Id3	Mus musculus	P41133	Anti Tag CoIP	23824195

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00717	ANKRD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ankrd2	NCBI	NCBI:26287