PSPH - phosphoserine phosphatase Gene

Also Known as PSP; PSPHD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5723

About PSPH

Cytogenetic location: 7p11.2 Genomic coordinates (GRCh38): 7:56,011,064-56,051,444 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues and is associated with 4 phenotypes. Ubiquitous expression in kidney (RPKM 3.8), thyroid (RPKM 3.1) and 25 other tissues.

Summary

The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]

PSPH Products (21)

mRNA Protein Name
NM_001370503.1 NP_001357432.1 phosphoserine phosphatase
NM_001370504.1 NP_001357433.1 phosphoserine phosphatase
NM_001370505.1 NP_001357434.1 phosphoserine phosphatase
NM_001370506.1 NP_001357435.1 phosphoserine phosphatase
NM_001370507.1 NP_001357436.1 phosphoserine phosphatase
NM_001370508.1 NP_001357437.1 phosphoserine phosphatase
NM_001370509.1 NP_001357438.1 phosphoserine phosphatase
NM_001370510.1 NP_001357439.1 phosphoserine phosphatase
NM_001370511.1 NP_001357440.1 phosphoserine phosphatase
NM_001370512.1 NP_001357441.1 phosphoserine phosphatase
NM_001370513.1 NP_001357442.1 phosphoserine phosphatase
NM_001370514.1 NP_001357443.1 phosphoserine phosphatase
NM_001370515.1 NP_001357444.1 phosphoserine phosphatase
NM_001370516.1 NP_001357445.1 phosphoserine phosphatase
NM_001370517.1 NP_001357446.1 phosphoserine phosphatase
NM_001370518.1 NP_001357447.1 phosphoserine phosphatase
NM_001370519.1 NP_001357448.1 phosphoserine phosphatase
NM_001370520.1 NP_001357449.1 phosphoserine phosphatase
NM_001370521.1 NP_001357450.1 phosphoserine phosphatase
NM_001370522.1 NP_001357451.1 phosphoserine phosphatase
NM_004577.4 NP_004568.2 phosphoserine phosphatase

PSPH Protein Structure

HAD

HAD: haloacid dehalogenase-like hydrolase (17 - 186)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

phosphoserine phosphatase

  • L-3-phosphoserine phosphatase

PSPH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PSPH P78330 RPS28 Homo sapiens P62857
Anti Bait CoIP
17353931
Intra
PSPH P78330 51492825 Homo sapiens 51492825
Anti Bait CoIP
17353931
Intra
PSPH P78330 PSPH Homo sapiens P78330
Y2H Array
31515488
Intra
PSPH P78330 CAP2 Homo sapiens P40123
Anti Bait CoIP
17353931
Intra
PSPH P78330 q65zq1_human Homo sapiens EBI-1054063
Anti Bait CoIP
17353931
Intra
PSPH P78330 IGF2BP1 Homo sapiens Q9NZI8
Anti Bait CoIP
17353931
Intra
PSPH P78330 MOB1A Homo sapiens Q9H8S9
Anti Bait CoIP
17353931
Intra
PSPH P78330 RPS9 Homo sapiens P46781
Anti Bait CoIP
17353931
Intra
PSPH P78330 CIRBP Homo sapiens Q14011
Anti Bait CoIP
17353931
Intra
PSPH P78330 PSPH Homo sapiens P78330
Y2H Array
25416956
Intra
PSPH P78330 PSPH Homo sapiens P78330
Y2H Array
25502805
Intra
PSPH P78330 ERH Homo sapiens P84090
Anti Bait CoIP
17353931
Intra
PSPH P78330 E7 Human papillomavirus P06429
Y2H Pooling
22898364
Intra
PSPH P78330 ASF1B Homo sapiens Q9NVP2
Anti Bait CoIP
17353931
Intra
PSPH P78330 ATXN1 Homo sapiens P54253
Y2H Prey Pooling
23275563
Intra
PSPH P78330 PRPSAP1 Homo sapiens Q14558
Anti Bait CoIP
17353931
Intra
PSPH P78330 TXN Homo sapiens P10599
Anti Bait CoIP
17353931
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PSPH Proteins

Cat. No. Product Name Accession Purity
HY-P71241 PSP Protein, Human (His) P78330 (M1-E225) ≥ 90%, as determined by reducing SDS-PAGE.

PSPH Antibodies

Cat. No. Product Name Application Reactivity
HY-P811240 PSPH Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Phosphoserine Phosphatase Deficiency

  • PSPHD

  • Deficiency Of Phosphoserine Phosphatase

  • Psph Deficiency

  • 3-Phosphoserine Phosphatase Deficiency, Infantile/Juvenile Form

  • Psph Deficiency, Infantile/Juvenile Form

  • Deficiency, Phosphoserine Phosphatase
Serine Deficiency
Lacrimal Gland Carcinoma

  • Lacrimal Gland Cancer

  • Carcinoma Of The Lacrimal Gland

  • Malignant Neoplasm Of Lacrimal Gland

  • Malignant Tumour Of Lacrimal Gland

  • Neoplasm Of Lacrimal Gland

  • Tumor Of The Lacrimal Gland

  • Malignant Tumor Of Lacrimal Gland
Phosphoserine Aminotransferase Deficiency

  • Psat Deficiency

  • PSATD

  • Phosphoserine Aminotransferase Deficiency, Infantile/Juvenile Form

  • Psat Deficiency, Infantile/Juvenile Form

  • Deficiency, Phosphoserine Aminotransferase
Phosphoglycerate Dehydrogenase Deficiency

  • Phgdh Deficiency

  • 3-Phosphoglycerate Dehydrogenase Deficiency

  • PHGDHD

  • 3-Pgdh Deficiency

  • 3-Phosphoglycerate Dehydrogenase Deficiency, Infantile/Juvenile Form

  • Phgdh Deficiency, Infantile/Juvenile Form

  • Deficiency, Phosphoglycerate Dehydrogenase
Neu-Laxova Syndrome 1

  • Neu-Laxova Syndrome

  • NLS1

  • Nls

  • Neu Laxova Syndrome

  • 3-Phosphoglycerate Dehydrogenase Deficiency, Neonatal Form
Lacrimal Gland Adenoid Cystic Carcinoma

  • Adenoid Cystic Carcinoma Of Lacrimal Gland
Lacrimal Gland Adenocarcinoma

  • Adenocarcinoma Of Lacrimal Gland
Ventriculomegaly With Cystic Kidney Disease

  • VMCKD

  • Cystic Kidney Disease With Ventriculomegaly

  • Ventriculomegaly-Cystic Kidney Disease

  • Ventriculomegaly - Cystic Kidney Disease

  • Congenital Nephrosis-Cerebral Ventriculomegaly Syndrome
Lacrimal System Cancer

  • Neoplasm Of Lacrimal System

  • Lacrimal System Neoplasm

  • Tumor Of The Lacrimal System
Meier-Gorlin Syndrome 1

  • Meier-Gorlin Syndrome

  • Ear, Patella, Short Stature Syndrome

  • Microtia, Absent Patellae, Micrognathia Syndrome

  • MGORS1

  • Eps

  • Ear-Patella-Short Stature Syndrome

  • Ear Patella Short Stature Syndrome

  • Microtia Absent Patellae Micrognathia Syndrome

  • Meier-Gorlin Syndrome, Type 1
Molybdenum Cofactor Deficiency, Complementation Group A

  • MOCODA

  • Sulfite Oxidase Deficiency Due To Molybdenum Cofactor Deficiency Type A

  • Molybdenum Cofactor Deficiency A

  • Molybdenum Cofactor Deficiency Type A

  • Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Type A

  • Mocod Type A

  • Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase, And Aldehyde Oxidase

  • Sulfite Oxidase, Xanthine Dehydrogenase, And Aldehyde Oxidase, Combined Deficiency Of

  • Molybdenum Cofactor Deficiency Complementation Group A

  • Molybdenum Cofactor Deficiency, Type A

  • Deficiency, Molybdenum Cofactor, Complementation Group A
Neu-Laxova Syndrome 2

  • NLS2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris PSPH VGNC VGNC:45124
Felis catus PSPH VGNC VGNC:80675
Mus musculus PSPH MGD MGI:97788
Bos taurus PSPH VGNC VGNC:33483
Rattus norvegicus PSPH RGD RGD:1308764
Others PSPH NCBI