CAP2 - cyclase associated actin cytoskeleton regulatory protein 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10486

About CAP2

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:17,393,595-17,557,780 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in brain (RPKM 40.2), heart (RPKM 39.1) and 15 other tissues.

Summary

This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. [provided by RefSeq, Jul 2008]

CAP2 Products (3)

mRNA Protein Name
NM_001363533.2 NP_001350462.1 adenylyl cyclase-associated protein 2 isoform 3
NM_001363534.2 NP_001350463.1 adenylyl cyclase-associated protein 2 isoform 2
NM_006366.3 NP_006357.1 adenylyl cyclase-associated protein 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAP2 Protein Structure

CAP_N

CAP_N: Adenylate cyclase associated (CAP) N terminal (4 - 310)

CAP_C

CAP_C: Adenylate cyclase associated (CAP) C terminal (322 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 477 a.a.
Protein Preferred Names Protein Names

adenylyl cyclase-associated protein 2

  • 2810452G09Rik

CAP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CAP2 P40123 CFL2 Homo sapiens Q549N0
Y2H Array
25416956
Intra
CAP2 P40123 CFL2 Homo sapiens Q549N0
Y2H Prey Pooling
25416956
Intra
CAP2 P40123 CFL2 Homo sapiens Q549N0
Validated Y2H
25416956
Intra
CAP2 P40123 ACTG1 Homo sapiens P63261
Validated Y2H
25416956
Intra
CAP2 P40123 ACTG1 Homo sapiens P63261
Y2H Prey Pooling
32296183
Intra
CAP2 P40123 ACTG1 Homo sapiens P63261
Validated Y2H
32296183
Intra
CAP2 P40123 CAP2 Homo sapiens P40123
Y2H Prey Pooling
32296183
Intra
CAP2 P40123 ACTG1 Homo sapiens P63261
Y2H Array
32296183
Intra
CAP2 P40123 CAP2 Homo sapiens P40123
Y2H Array
25416956
Intra
CAP2 P40123 ACTB Homo sapiens P60709
Anti Tag CoIP
28514442
Intra
CAP2 P40123 ACTB Homo sapiens P60709
Anti Tag CoIP
33961781
Intra
CAP2 P40123 CAP2 Homo sapiens P40123
Y2H Array
32296183
Intra
CAP2 P40123 ACTG1 Homo sapiens P63261
Y2H Prey Pooling
25416956
Intra
CAP2 P40123 ADO Homo sapiens Q96SZ5
Validated Y2H
32296183
Intra
CAP2 P40123 ALAS1 Homo sapiens P13196
Y2H Array
32296183
Intra
CAP2 P40123 ALAS1 Homo sapiens P13196
Y2H Prey Pooling
32296183
Intra
CAP2 P40123 PS1TP5BP1 Homo sapiens Q1KLZ0
Y2H Prey Pooling
25416956
Intra
CAP2 P40123 PS1TP5BP1 Homo sapiens Q1KLZ0
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

CAP2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80581 CAP2 Antibody (YA568) WB, FC, IP Human
HY-P80581A CAP2 Antibody (YA568)(PBS only) WB, FC, IP Human

Related Diseases

Diseases Alias
Familial Isolated Dilated Cardiomyopathy

  • Familial Or Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70081 mRNA Cap 2'-O-methyltransferase / Unkown
HY-159855 CAP 2 hydrochloride 97.6% Unkown
HY-149263 HAA-09 Inhibitor / Unkown
HY-RS01881 CAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01900 CAPS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12716 SERPINB8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14771 TMPRSS4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17580 Cap2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18442 Tmprss4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19851 Serpinb8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24040 Cap2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CAP2 VGNC VGNC:60347
Canis familiaris CAP2 VGNC VGNC:38696
Rattus norvegicus CAP2 RGD RGD:620310
Mus musculus CAP2 MGD MGI:1914502
Bos taurus CAP2 VGNC VGNC:26738
Macaca mulatta CAP2 VGNC VGNC:70584
Others CAP2 NCBI