PTPRZ1 - protein tyrosine phosphatase receptor type Z1 Gene

Homo sapiens

Also known as PTPZ; HPTPZ; PTP18; PTPRZ; RPTPB; HPTPzeta; PTP-ZETA; RPTPbeta; phosphacan; R-PTP-zeta-2

Gene ID: 5803 | Gene type: protein coding

About PTPRZ1

Cytogenetic location: 7q31.32 Genomic coordinates (GRCh38): 7:121,873,161-122,062,036 (from NCBI)

This gene has 21 transcripts (splice variants), 290 orthologues and 35 paralogues. Biased expression in brain (RPKM 103.2) and skin (RPKM 10.8).

Summary

This gene encodes a member of the receptor protein tyrosine Phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

PTPRZ1 Products(5)

mRNA	Protein	Name
NM_001206838.2	NP_001193767.1	receptor-type tyrosine-protein phosphatase zeta isoform 2 precursor
NM_001206839.2	NP_001193768.1	receptor-type tyrosine-protein phosphatase zeta isoform 3 precursor
NM_001369395.1	NP_001356324.1	receptor-type tyrosine-protein phosphatase zeta isoform 4 precursor
NM_001369396.1	NP_001356325.1	receptor-type tyrosine-protein phosphatase zeta isoform 5
NM_002851.3	NP_002842.2	receptor-type tyrosine-protein phosphatase zeta isoform 1 precursor

PTPRZ1 Protein Structure

Carb_anhydrase

fn3

Y_phosphatase

0
400
800
1200
1600
2000
2315 a.a.

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase zeta

protein tyrosine phosphatase, receptor-type, Z polypeptide 1

Recombinant PTPRZ1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71777	PTPRZ1 Protein, Human (P.pastoris, His)	P23471 (36I-300Y)	≥95%

Related Diseases

Diseases

Alias

Generalized Epilepsy With Febrile Seizures Plus, Type 1

GEFSP1	GEFS+1
Generalized Epilepsy With Febrile Seizures Plus 1	Gefs+, Type 1
Generalised Epilepsy With Febrile Seizures Plus 1	Generalised Epilepsy With Febrile Seizures Plus Type 1
Generalized Epilepsy With Febrile Seizures Plus Type 1	Gefs+ Type 1
Epilepsy, Generalized, With Febrile Seizures Plus, Type 1

Oligodendroglioma

Oligodendroglial Neoplasm	Oligodendroglial Tumor
Oligodendroglial Tumors	Well Differentiated Oligodendroglioma

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Generalized Epilepsy With Febrile Seizures Plus

Gefs+	Genetic Epilepsy With Febrile Seizures Plus
Generalized Epilepsy With Febrile Seizures-Plus	Genetic Epilepsy With Febrile Seizures-Plus
Epilepsy, Generalized, With Febrile Seizures Plus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11452	PTPRZ1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PTPRZ1	VGNC	VGNC:76625
Canis familiaris	PTPRZ1	VGNC	VGNC:54793
Bos taurus	PTPRZ1	VGNC	VGNC:33560
Felis catus	PTPRZ1	VGNC	VGNC:69184
Mus musculus	PTPRZ1	MGD	MGI:97816
Rattus norvegicus	PTPRZ1	RGD	RGD:3455
Others	PTPRZ1	NCBI

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