PTPRZ1 - protein tyrosine phosphatase receptor type Z1 Gene

Also Known as PTPZ; HPTPZ; PTP18; PTPRZ; RPTPB; HPTPzeta; PTP-ZETA; RPTPbeta; phosphacan; R-PTP-zeta-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5803

About PTPRZ1

Cytogenetic location: 7q31.32 Genomic coordinates (GRCh38): 7:121,873,161-122,062,036 (from NCBI)

This gene has 21 transcripts (splice variants), 290 orthologues and 35 paralogues. Biased expression in brain (RPKM 103.2) and skin (RPKM 10.8).

Summary

This gene encodes a member of the receptor protein tyrosine Phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

PTPRZ1 Products (5)

mRNA Protein Name
NM_001206838.2 NP_001193767.1 receptor-type tyrosine-protein phosphatase zeta isoform 2 precursor
NM_001206839.2 NP_001193768.1 receptor-type tyrosine-protein phosphatase zeta isoform 3 precursor
NM_001369395.1 NP_001356324.1 receptor-type tyrosine-protein phosphatase zeta isoform 4 precursor
NM_001369396.1 NP_001356325.1 receptor-type tyrosine-protein phosphatase zeta isoform 5
NM_002851.3 NP_002842.2 receptor-type tyrosine-protein phosphatase zeta isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IDA
IDA: Inferred from direct assay
19141530 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10706604 GOA
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
10706604 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
19141530 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRZ1 Protein Structure

Carb_anhydrase

Carb_anhydrase: Eukaryotic-type carbonic anhydrase (38 - 299)

fn3

fn3: Fibronectin type III domain (313 - 401)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (1750 - 1990)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (2048 - 2280)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2315 a.a.
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase zeta

  • protein tyrosine phosphatase, receptor-type, Z polypeptide 1

PTPRZ1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTPRZ1 P23471 ALK Homo sapiens Q9UM73
Phosphatase Assay
17681947
Intra
PTPRZ1 P23471 CNTN1 Homo sapiens Q12860
X-Ray Diffraction
21969550
Intra
PTPRZ1 P23471 CNTN1 Homo sapiens Q12860
Pull Down
21969550
Intra
PTPRZ1 P23471 CNTN1 Homo sapiens Q12860
GMS
21969550
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPRZ1 Proteins

Cat. No. Product Name Accession Purity
HY-P71777 PTPRZ1 Protein, Human (P.pastoris, His) P23471-1 (I36-Y300) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Generalized Epilepsy With Febrile Seizures Plus, Type 1

  • GEFSP1

  • GEFS+1

  • Generalized Epilepsy With Febrile Seizures Plus 1

  • Gefs+, Type 1

  • Generalised Epilepsy With Febrile Seizures Plus 1

  • Generalised Epilepsy With Febrile Seizures Plus Type 1

  • Generalized Epilepsy With Febrile Seizures Plus Type 1

  • Gefs+ Type 1

  • Epilepsy, Generalized, With Febrile Seizures Plus, Type 1
Oligodendroglioma

  • Oligodendroglial Neoplasm

  • Oligodendroglial Tumor

  • Oligodendroglial Tumors

  • Well Differentiated Oligodendroglioma
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Generalized Epilepsy With Febrile Seizures Plus

  • Gefs+

  • Genetic Epilepsy With Febrile Seizures Plus

  • Generalized Epilepsy With Febrile Seizures-Plus

  • Genetic Epilepsy With Febrile Seizures-Plus

  • Epilepsy, Generalized, With Febrile Seizures Plus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123856 MY10 99.86% Unkown
HY-RS11452 PTPRZ1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17478 Ptprz1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23936 Ptprz1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PTPRZ1 VGNC VGNC:76625
Canis familiaris PTPRZ1 VGNC VGNC:54793
Bos taurus PTPRZ1 VGNC VGNC:33560
Felis catus PTPRZ1 VGNC VGNC:69184
Mus musculus PTPRZ1 MGD MGI:97816
Rattus norvegicus PTPRZ1 RGD RGD:3455
Others PTPRZ1 NCBI