Crhr1 - corticotropin releasing hormone receptor 1 Gene

Also Known as CRF1; CRF-R; CRFR1; CRH-R; CRF-R1; CRFR-1; CRH-R1; CRF-R-1; CRH-R 1; CRH-R-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58959

About Crhr1

Primary_assembly 10: 89,040,203-89,083,481 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 239 orthologues, 42 paralogues and is associated with 29 phenotypes. Restricted expression toward (RPKM 31.6).

Summary

This gene encodes a member of the G-protein coupled receptor family. The encoded protein is a receptor for corticotropin-releasing factor (CRH) and urocortin (UCN). The interaction of this protein with CRH and UCN triggers G-protein coupled signaling. This protein plays a pivotal role in mediating the CRH-elicited effects in depression and anxiety. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Crhr1 Products (2)

mRNA Protein Name
NM_001301812.2 NP_001288741.2 corticotropin-releasing factor receptor 1 isoform 2 precursor
NM_030999.5 NP_112261.2 corticotropin-releasing factor receptor 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
11902119 RGD
enables G-protein alpha-subunit binding IPI
IPI: Inferred from physical interaction
20548297 RGD
enables corticotropin-releasing hormone binding IDA
IDA: Inferred from direct assay
12942143 RGD
enables corticotropin-releasing hormone receptor activity IDA
IDA: Inferred from direct assay
12942143 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
15049707 RGD
enables peptide binding IPI
IPI: Inferred from physical interaction
15932935 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
24290358 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
20548297 RGD
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15932935 RGD
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11784785 RGD
involved in behavioral response to cocaine IMP
IMP: Inferred from mutant phenotype
21813699 RGD
involved in behavioral response to pain IMP
IMP: Inferred from mutant phenotype
17550594 RGD
involved in epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
20551459 RGD
involved in feeding behavior IMP
IMP: Inferred from mutant phenotype
12559107 RGD
involved in hypothalamus development IEP
IEP: Inferred from expression pattern
20002962 RGD
involved in locomotory exploration behavior IMP
IMP: Inferred from mutant phenotype
9299637 RGD
involved in long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
19376201 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
15932935 RGD
involved in negative regulation of epinephrine secretion IMP
IMP: Inferred from mutant phenotype
12606499 RGD
involved in negative regulation of feeding behavior IMP
IMP: Inferred from mutant phenotype
14512273 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11784785 RGD
involved in neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
11784785 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15932935 RGD
involved in positive regulation of cAMP/PKA signal transduction IMP
IMP: Inferred from mutant phenotype
20682782 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
16513211 RGD
involved in positive regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
18209484 RGD
involved in regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
17079348 RGD
involved in response to electrical stimulus IMP
IMP: Inferred from mutant phenotype
17015825 RGD
involved in response to hypoxia IMP
IMP: Inferred from mutant phenotype
16099461 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
21664419 RGD
involved in visual learning IMP
IMP: Inferred from mutant phenotype
15932935 RGD
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
12911751 RGD
located in dendrite IDA
IDA: Inferred from direct assay
12911751 RGD
NOT located in dendritic spine IDA
IDA: Inferred from direct assay
12911751 RGD
located in multivesicular body IDA
IDA: Inferred from direct assay
12911751 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12911751 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
12911751 RGD
located in vesicle IDA
IDA: Inferred from direct assay
12911751 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

corticotropin-releasing factor receptor 1

  • corticotrophin releasing hormone receptor 1

  • corticotropin releasing hormone 1

Crhr1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Crhr1 P35353 Ucn Rattus norvegicus P55090
Crosslink
24290358
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103377 Antalarmin hydrochloride Antagonist 99.87% Unkown
HY-124475 Antalarmin Antagonist 99.95% Unkown
HY-12131 DMP 696 Antagonist 99.03% Unkown
HY-RS03168 CRHR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03169 Crhr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03170 Crhr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-139035 CRHR1 antagonist 1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crhr1 NCBI NCBI:1394