DMP 696
Based on 1 publication(s) in Google Scholar
DMP 696 is a selective corticotropin-releasing hormone receptor 1 (CRHR1) antagonist, used for the treatment of anxiety and depression.
For research use only. We do not sell to patients.
- Purity: 98.11%
- CAS No.: 202578-52-7
- Formula: C18H21Cl2N5O2
- Molecular Weight:410.30
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
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GPCR/G Protein Compound Library
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Publications Citing Use of MedChemExpress (MCE) DMP 696
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 202578-52-7
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Appearance Solid
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Molecular Weight 410.30
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Formula C18H21Cl2N5O2
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SMILES
CC1=NN2C(N=C(C)N=C2NC(COC)COC)=C1C3=CC=C(Cl)C=C3Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Immunity
Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response. [Abstract]2024 Feb 13;57(2):364-378.e9. PMID: 38301651
Solvent & Solubility
DMSO : 100 mg/mL (243.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
DMP696 is dissolved in saccharose-flavored NaCl 0.9% containing 10% DMSO, 10% PEG 400, and Tween-80 (1 drop/mL). Drug suspension is delivered on an oat flake and then fed to animals at a final dose of 3 mg/kg. Controls receive an oat flake soaked with saccharose-flavored vehicle only. The dose of 3 mg/kg is chosen on the basis of pilot experiments in which doses of 3, 10, and 30 mg/kg have been compared. The drug solutions are always freshly pipetted onto the flake and shortly dried before delivery. Ad libitum-fed mice receive some saccharose-flavored oat flakes 2 days before starting an experiment to habituate them to the novel food. Over the course of treatment, mice show no signs of aversion against the drug-soaked flakes, but readily ate them within a few seconds after delivery.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Thoeringer CK, et al. Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus. Neuropsychopharmacology. 2012 Feb;37(3):787-96. [Content Brief]
[2]. Hubbard DT, et al. Activation of basolateral amygdala corticotropin-releasing factor 1 receptors modulates the consolidation of contextual fear. Neuroscience. 2007 Dec 19;150(4):818-28. Epub 2007 Oct 5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4372 mL | 12.1862 mL | 24.3724 mL | 60.9310 mL |
| 5 mM | 0.4874 mL | 2.4372 mL | 4.8745 mL | 12.1862 mL | |
| 10 mM | 0.2437 mL | 1.2186 mL | 2.4372 mL | 6.0931 mL | |
| 15 mM | 0.1625 mL | 0.8124 mL | 1.6248 mL | 4.0621 mL | |
| 20 mM | 0.1219 mL | 0.6093 mL | 1.2186 mL | 3.0466 mL | |
| 25 mM | 0.0975 mL | 0.4874 mL | 0.9749 mL | 2.4372 mL | |
| 30 mM | 0.0812 mL | 0.4062 mL | 0.8124 mL | 2.0310 mL | |
| 40 mM | 0.0609 mL | 0.3047 mL | 0.6093 mL | 1.5233 mL | |
| 50 mM | 0.0487 mL | 0.2437 mL | 0.4874 mL | 1.2186 mL | |
| 60 mM | 0.0406 mL | 0.2031 mL | 0.4062 mL | 1.0155 mL | |
| 80 mM | 0.0305 mL | 0.1523 mL | 0.3047 mL | 0.7616 mL | |
| 100 mM | 0.0244 mL | 0.1219 mL | 0.2437 mL | 0.6093 mL |
DMP 696 Related Classifications
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