Nherf1 - NHERF family PDZ scaffold protein 1 Gene

Also Known as Slc9a3r1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59114

Summary

Enables several functions, including PDZ domain binding activity; Myosin II binding activity; and protein N-terminus binding activity. Contributes to gamma-aminobutyric acid transmembrane transporter activity. Involved in gamma-aminobutyric acid import; import across plasma membrane; and positive regulation of ion transmembrane transport. Located in several cellular components, including apical plasma membrane; membrane raft; and microvillus membrane. Part of plasma membrane protein complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Orthologous to human SLC9A3R1 (SLC9A3 regulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Nherf1 Products (1)

mRNA Protein Name
NM_021594.1 NP_067605.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
21325834 RGD
contributes to gamma-aminobutyric acid transmembrane transporter activity IGI
IGI: Inferred from genetic interaction
29491210 RGD
enables molecular adaptor activity IMP
IMP: Inferred from mutant phenotype
21325834 RGD
enables myosin II binding IDA
IDA: Inferred from direct assay
21598299 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11457882 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
22904329 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
21372499 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
16234233 RGD
Biological Process GO Annotation Evidence References Source
involved in gamma-aminobutyric acid import IGI
IGI: Inferred from genetic interaction
29491210 RGD
involved in import across plasma membrane IGI
IGI: Inferred from genetic interaction
29491210 RGD
involved in positive regulation of monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
16234233 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
20404332 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
21120533 RGD
located in microvillus membrane IDA
IDA: Inferred from direct assay
11726633 RGD
part of plasma membrane protein complex IPI
IPI: Inferred from physical interaction
29491210 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

  • EBP50

  • ERM-binding phosphoprotein

  • NHERF-1

  • SLC9A3 regulator 1

  • ezrin-radixin-moesin-binding phosphoprotein 50

  • regulatory cofactor of Na(+)/H(+) exchanger

  • sodium-hydrogen exchanger regulatory factor 1

  • solute carrier family 9 (sodium/hydrogen exchanger)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150269 RS5517 Inhibitor 95.79% Unkown
HY-182624 FJ9 / Unkown
HY-RS09282 NHERF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10226 PGD97 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nherf1 NCBI NCBI:9368