Nherf1 - NHERF family PDZ scaffold protein 1 Gene

Rattus norvegicus

Also known as Slc9a3r1

Gene ID: 59114 | Gene type: protein coding

About Nherf1

Summary

Enables several functions, including PDZ domain binding activity; Myosin II binding activity; and protein N-terminus binding activity. Contributes to gamma-aminobutyric acid transmembrane transporter activity. Involved in gamma-aminobutyric acid import; import across plasma membrane; and positive regulation of ion transmembrane transport. Located in several cellular components, including apical plasma membrane; membrane raft; and microvillus membrane. Part of plasma membrane protein complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Orthologous to human SLC9A3R1 (SLC9A3 regulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Nherf1 Products(1)

mRNA	Protein	Name
NM_021594.1	NP_067605.1	Na(+)/H(+) exchange regulatory cofactor NHE-RF1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	21325834	RGD
contributes to gamma-aminobutyric acid transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	29491210	RGD
enables molecular adaptor activity	IMP IMP: Inferred from mutant phenotype	21325834	RGD
enables myosin II binding	IDA IDA: Inferred from direct assay	21598299	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11457882	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	22904329	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	21372499	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	16234233	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in gamma-aminobutyric acid import	IGI IGI: Inferred from genetic interaction	29491210	RGD
involved in import across plasma membrane	IGI IGI: Inferred from genetic interaction	29491210	RGD
involved in positive regulation of monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	16234233	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	20404332	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	21120533	RGD
located in microvillus membrane	IDA IDA: Inferred from direct assay	11726633	RGD
part of plasma membrane protein complex	IPI IPI: Inferred from physical interaction	29491210	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

EBP50	ERM-binding phosphoprotein
NHERF-1	SLC9A3 regulator 1
ezrin-radixin-moesin-binding phosphoprotein 50	regulatory cofactor of Na(+)/H(+) exchanger
sodium-hydrogen exchanger regulatory factor 1	solute carrier family 9 (sodium/hydrogen exchanger)

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150269	RS5517	Inhibitor	95.79%	Unkown
HY-182624	FJ9		/	Unkown
HY-RS09282	NHERF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10226	PGD97		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nherf1	NCBI	NCBI:9368

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