BDKRB1 - bradykinin receptor B1 Gene

Homo sapiens

Also known as B1R; BKR1; B1BKR; BKB1R; BRADYB1

Gene ID: 623 | Gene type: protein coding

About BDKRB1

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:96,256,210-96,264,763 (from NCBI)

This gene has 4 transcripts (splice variants), 147 orthologues and 7 paralogues. Biased expression in gall bladder (RPKM 7.4), urinary bladder (RPKM 5.2) and 12 other tissues.

Summary

Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. [provided by RefSeq, Aug 2020]

BDKRB1 Products(2)

mRNA	Protein	Name
NM_001386007.1	NP_001372936.1	B1 bradykinin receptor
NM_000710.4	NP_000701.2	B1 bradykinin receptor

BDKRB1 Protein Structure

7tm_1

0
100
200
300
353 a.a.

Protein Preferred Names

Protein Names

B1 bradykinin receptor

BK-1 receptor	bradykinin B1 receptor
bradykinin receptor 1

Related Diseases

Diseases

Alias

Erysipelas

Milker'S Nodule

Poxviridae Infections	Milker Nodule
Milkers' Node	Paravaccinia
Pseudocowpox	Milker'S Nodes

Angioedema

Angioneurotic Oedema	Quincke'S Edema
Angioneurotic Edema	Giant Urticaria

Covid-19

2019 Novel Coronavirus	2019-Ncov Infection
Covid19	Sars-Cov-2 Infection
Wuhan Coronavirus Infection	Wuhan Seafood Market Pneumonia Virus Infection

End Stage Renal Disease

End Stage Renal Failure	End-Stage Kidney Disease
Kidney Failure, Chronic	Chronic Kidney Disease Stage 5

Hereditary Angioedema

Hereditary Angioneurotic Edema	Hereditary Angioedema Type 1
Hane	Angioedema, Hereditary
Hae	Angioedemas, Hereditary
Deficiency Of C1 Esterase Inhibitor	C1 Esterase Inhibitor Deficiency
C1 Inhibitor Deficiency	Familial Angioneurotic Edema
Hereditary Bradykinine-Induced Angioedema	Hereditary Non Histamine-Induced Angioedema
Hae 1	Hae-I
Hereditary Angioneurotic Edema Type 1	Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor
Hereditary Angioedema Types I And Ii	Hereditary Angioneurotic Oedema
Familial Angioedema	Hae - [Hereditary Angioneurotic Oedema]
Bannister Disease, Hereditary	Quincke Disease Or Oedema
Hereditary Quincke Oedema

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS01454	BDKRB1 Human Pre-designed siRNA Set A	/	Unkown
HY-RS01455	Bdkrb1 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS01456	Bdkrb1 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BDKRB1	VGNC	VGNC:26459
Rattus norvegicus	BDKRB1	RGD	RGD:620401
Mus musculus	BDKRB1	MGD	MGI:88144
Canis familiaris	BDKRB1	VGNC	VGNC:38424
Macaca mulatta	BDKRB1	VGNC	VGNC:70043

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