BDKRB1 - bradykinin receptor B1 Gene

Also Known as B1R; BKR1; B1BKR; BKB1R; BRADYB1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 623

About BDKRB1

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:96,256,210-96,264,763 (from NCBI)

This gene has 4 transcripts (splice variants), 147 orthologues and 7 paralogues. Biased expression in gall bladder (RPKM 7.4), urinary bladder (RPKM 5.2) and 12 other tissues.

Summary

Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. [provided by RefSeq, Aug 2020]

BDKRB1 Products (2)

mRNA Protein Name
NM_001386007.1 NP_001372936.1 B1 bradykinin receptor
NM_000710.4 NP_000701.2 B1 bradykinin receptor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables bradykinin receptor activity IDA
IDA: Inferred from direct assay
1314587 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23597562 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BDKRB1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (54 - 312)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
Protein Preferred Names Protein Names

B1 bradykinin receptor

  • BK-1 receptor

  • bradykinin B1 receptor

  • bradykinin receptor 1

BDKRB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BDKRB1 P46663 P01042-PRO_0000006687 Homo sapiens P01042-PRO_0000006687
SPA
23597562
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Erysipelas
Milker'S Nodule

  • Poxviridae Infections

  • Milker Nodule

  • Milkers' Node

  • Paravaccinia

  • Pseudocowpox

  • Milker'S Nodes
Angioedema

  • Angioneurotic Oedema

  • Quincke'S Edema

  • Angioneurotic Edema

  • Giant Urticaria
Covid-19

  • 2019 Novel Coronavirus

  • 2019-Ncov Infection

  • Covid19

  • Sars-Cov-2 Infection

  • Wuhan Coronavirus Infection

  • Wuhan Seafood Market Pneumonia Virus Infection
End Stage Renal Disease

  • End Stage Renal Failure

  • End-Stage Kidney Disease

  • Kidney Failure, Chronic

  • Chronic Kidney Disease Stage 5
Hereditary Angioedema

  • Hereditary Angioneurotic Edema

  • Hereditary Angioedema Type 1

  • Hane

  • Angioedema, Hereditary

  • Hae

  • Angioedemas, Hereditary

  • Deficiency Of C1 Esterase Inhibitor

  • C1 Esterase Inhibitor Deficiency

  • C1 Inhibitor Deficiency

  • Familial Angioneurotic Edema

  • Hereditary Bradykinine-Induced Angioedema

  • Hereditary Non Histamine-Induced Angioedema

  • Hae 1

  • Hae-I

  • Hereditary Angioneurotic Edema Type 1

  • Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

  • Hereditary Angioedema Types I And Ii

  • Hereditary Angioneurotic Oedema

  • Familial Angioedema

  • Hae - [Hereditary Angioneurotic Oedema]

  • Bannister Disease, Hereditary

  • Quincke Disease Or Oedema

  • Hereditary Quincke Oedema
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P4676 Lys-(Des-Arg9,Leu8)-Bradykinin Antagonist 99.78% Unkown
HY-P4676A Lys-(Des-Arg9,Leu8)-Bradykinin TFA Antagonist / Unkown
HY-RS01454 BDKRB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01455 Bdkrb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01456 Bdkrb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus BDKRB1 VGNC VGNC:26459
Rattus norvegicus BDKRB1 RGD RGD:620401
Mus musculus BDKRB1 MGD MGI:88144
Canis familiaris BDKRB1 VGNC VGNC:38424
Macaca mulatta BDKRB1 VGNC VGNC:70043
Others BDKRB1 NCBI