FGFR2 - fibroblast growth factor receptor 2 Gene

Macaca mulatta

Gene ID: 715949 | Gene type: protein coding

About FGFR2

Primary_assembly 9: 121,952,900-122,068,929 reverse strand.Mmul_10:CM014344.1

This gene has 4 transcripts (splice variants), 221 orthologues and 53 paralogues.

FGFR2 Products(21)

mRNA	Protein	Name
XM_015148336.2	XP_015003822.1	fibroblast growth factor receptor 2 isoform X12
XM_015148328.2	XP_015003814.1	fibroblast growth factor receptor 2 isoform X2
XM_028826932.1	XP_028682765.1	fibroblast growth factor receptor 2 isoform X8
XM_015148335.2	XP_015003821.1	fibroblast growth factor receptor 2 isoform X11
XM_015148334.2	XP_015003820.1	fibroblast growth factor receptor 2 isoform X7
XM_028826933.1	XP_028682766.1	fibroblast growth factor receptor 2 isoform X9
XM_015148330.2	XP_015003816.1	fibroblast growth factor receptor 2 isoform X4
XM_028826928.1	XP_028682761.1	fibroblast growth factor receptor 2 isoform X1
XM_028826935.1	XP_028682768.1	fibroblast growth factor receptor 2 isoform X8
XM_028826936.1	XP_028682769.1	fibroblast growth factor receptor 2 isoform X10
XM_015148337.2	XP_015003823.1	fibroblast growth factor receptor 2 isoform X13
XM_015148333.2	XP_015003819.1	fibroblast growth factor receptor 2 isoform X6
XM_015148331.2	XP_015003817.1	fibroblast growth factor receptor 2 isoform X5
XM_015148327.2	XP_015003813.1	fibroblast growth factor receptor 2 isoform X1
XM_028826939.1	XP_028682772.1	fibroblast growth factor receptor 2 isoform X14
XM_015148329.2	XP_015003815.1	fibroblast growth factor receptor 2 isoform X3
XM_028826931.1	XP_028682764.1	fibroblast growth factor receptor 2 isoform X6
XM_028826937.1	XP_028682770.1	fibroblast growth factor receptor 2 isoform X9
XM_028826930.1	XP_028682763.1	fibroblast growth factor receptor 2 isoform X1
XM_028826926.1	XP_028682759.1	fibroblast growth factor receptor 2 isoform X1
XM_028826927.1	XP_028682760.1	fibroblast growth factor receptor 2 isoform X1

FGFR2 Protein Structure

IgI_1_FGFR

IgI_2_FGFR

PTKc_FGFR2

0
200
400
600
841 a.a.

Protein Preferred Names

Protein Names

fibroblast growth factor receptor 2

fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13311	Infigratinib		99.82%	Yes
HY-109099	Pemigatinib	Inhibitor	99.84%	Yes
HY-N0060	Ferulic acid	Inhibitor	99.97%	Yes
HY-100818	Futibatinib	Inhibitor	99.90%	Unkown
HY-13311A	Infigratinib phosphate	Inhibitor	99.59%	Yes
HY-N0060A	Ferulic acid sodium	Inhibitor	99.88%	Yes

Clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13330	Fexagratinib	Inhibitor	99.92%	Phase 3
HY-19981	Derazantinib	Inhibitor	99.41%	Phase 3
HY-100019	Rogaratinib	Inhibitor	99.86%	Phase 3
HY-15391	Lucitanib	Inhibitor	98.94%	Phase 3
HY-13034	Gandotinib	Inhibitor	99.86%	Phase 2
HY-13304	LY2874455	Inhibitor	99.14%	Phase 2
HY-10987A	ENMD-2076		99.99%	Phase 2
HY-19957	Zoligratinib	Inhibitor	99.76%	Phase 2
HY-10186	TG 100801	Inhibitor	98.61%	Phase 2
HY-10987	ENMD-2076 Tartrate		99.66%	Phase 2
HY-19981B	Derazantinib dihydrochloride	Inhibitor	/	Phase 2
HY-101466A	E7090 succinate	Inhibitor	99.17%	Phase 2
HY-10187	TG 100801 Hydrochloride	Inhibitor	/	Phase 2
HY-101768	PRN1371	Inhibitor	99.78%	Phase 1
HY-156632	Resigratinib	Inhibitor	99.53%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99010	Bemarituzumab	Inhibitor	99.82%	Phase 3
HY-P99007	Aprutumab	Inhibitor	99.00%	Phase 1

Pre-clinical Phase

Bioactive Molecules (89)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0183	Formononetin		99.21%	Unkown
HY-147250	Lirafugratinib	Inhibitor	99.67%	Unkown
HY-17601	Alofanib		99.32%	Unkown
HY-18602	FIIN-2	Inhibitor	99.32%	Unkown
HY-15813	FIIN-1	Inhibitor	99.04%	Unkown
HY-101466	E7090	Inhibitor	98.11%	Unkown
HY-107194	NSC12		99.27%	Unkown
HY-145231	FGFR2-IN-2	Inhibitor	98.25%	Unkown
HY-149843	LC-MB12		98.10%	Unkown
HY-10185	TG 100572 Hydrochloride	Inhibitor	98.76%	Unkown
HY-N7715	Ferulic acid acyl-β-D-glucoside		99.33%	Unkown
HY-148779	FGFR3-IN-5	Inhibitor	99.16%	Unkown
HY-147250A	Lirafugratinib hydrochloride	Inhibitor	98.96%	Unkown
HY-128979	Deruxtecan analog 2		99.56%	Unkown
HY-145230	FGFR2-IN-1	Inhibitor	99.78%	Unkown
HY-18603	FIIN-3	Inhibitor	99.01%	Unkown
HY-175743	TYRA-200	Inhibitor	98.06%	Unkown
HY-162865	FGFR2-IN-3	Inhibitor	98.28%	Unkown
HY-15391A	Lucitanib dihydrochloride	Inhibitor	98.12%	Unkown
HY-165298	DGY-09-192		99.50%	Unkown
HY-13311S	Infigratinib-d3	Inhibitor	98.90%	Unkown
HY-145043	FGFR-IN-1	Inhibitor	99.46%	Unkown
HY-163985	PROTAC FGFR2 degrader 1		95.04%	Unkown
HY-P11162	FGF7p		99.34%	Unkown
HY-10184	TG 100572	Inhibitor	/	Unkown
HY-101544	ARQ 069	Inhibitor	/	Unkown
HY-117595	PHM16		/	Unkown
HY-123134	FIIN-4	Inhibitor	/	Unkown
HY-141685	3-Methylthienyl-carbonyl-JNJ-7706621	Inhibitor	/	Unkown
HY-142921	FGFR-IN-2	Inhibitor	/	Unkown
HY-145425	PAIR2		/	Unkown
HY-146541	FGFR4-IN-10	Inhibitor	/	Unkown
HY-148597	FGFR-IN-10	Inhibitor	/	Unkown
HY-150652	FGFR-IN-8		/	Unkown
HY-151903S	FGFR2/3-IN-1	Inhibitor	/	Unkown
HY-152104	FGFR-IN-9	Inhibitor	/	Unkown
HY-152146	HDAC-IN-50		/	Unkown
HY-155028	FGFR-IN-11	Inhibitor	/	Unkown
HY-162577	FGFR-IN-14	Inhibitor	/	Unkown
HY-162626	FGFR2 degrader 1	Degrader	/	Unkown
HY-163273	FGFR4-IN-17	Inhibitor	/	Unkown
HY-163620	LHQ490		/	Unkown
HY-163986	Pomalidomide-C2-NHCO-C6		/	Unkown
HY-163989	N-Ethylheptanamide		/	Unkown
HY-168286	FGFR-IN-16	Inhibitor	/	Unkown
HY-170919	FGFR2/3-IN-2	Inhibitor	/	Unkown
HY-170934	BW710	Inhibitor	/	Unkown
HY-172916	LC-SF-14	Inhibitor	/	Unkown
HY-172921	FGFR-IN-18	Inhibitor	/	Unkown
HY-172922	FGFR-IN-19	Inhibitor	/	Unkown
HY-172923	FGFR-IN-20	Inhibitor	/	Unkown
HY-174154	INCB126503	Inhibitor	/	Unkown
HY-174974	ISM7594	Inhibitor	/	Unkown
HY-176547	FGFR2/3-IN-3	Inhibitor	/	Unkown
HY-176927	ADC-VI		/	Unkown
HY-177276	FGFR-IN-22	Inhibitor	/	Unkown
HY-178059	FGFR-IN-23		/	Unkown
HY-178238	LD2-3	Inhibitor	/	Unkown
HY-180794	LHQ766	Inhibitor	/	Unkown
HY-180972	PROTAC EML4-ALK Degrader-2	Inhibitor	/	Unkown
HY-181005	FGFR-IN-25		/	Unkown
HY-181031	FGFR-IN-24		/	Unkown
HY-181752	FGFR3-IN-12		/	Unkown
HY-182354	VEGFR2-IN-84	Inhibitor	/	Unkown
HY-182817	Len-604		/	Unkown
HY-182915	FGFR-IN-26	Inhibitor	/	Unkown
HY-183780	FGFR-IN-27		/	Unkown
HY-E70814	FGFR2 C491S Recombinant Human Active Protein Kinase		/	Unkown
HY-E70815	FGFR2 K526E Recombinant Human Active Protein Kinase		/	Unkown
HY-E70816	FGFR2 K641N Recombinant Human Active Protein Kinase		/	Unkown
HY-E70817	FGFR2 K641R Recombinant Human Active Protein Kinase		/	Unkown
HY-E70818	FGFR2 K659M Recombinant Human Active Protein Kinase		/	Unkown
HY-E70819	FGFR2 K659N Recombinant Human Active Protein Kinase		/	Unkown
HY-E70820	FGFR2 L617V Recombinant Human Active Protein Kinase		/	Unkown
HY-E70821	FGFR2 M537I Recombinant Human Active Protein Kinase		/	Unkown
HY-E70822	FGFR2 N549H Recombinant Human Active Protein Kinase		/	Unkown
HY-E70823	FGFR2 N549K Recombinant Human Active Protein Kinase		/	Unkown
HY-E70824	FGFR2 R612T Recombinant Human Active Protein Kinase		/	Unkown
HY-E70825	FGFR2 V564F Recombinant Human Active Protein Kinase		/	Unkown
HY-E70826	FGFR2 V564I Recombinant Human Active Protein Kinase		/	Unkown
HY-E70827	FGFR2 V564L Recombinant Human Active Protein Kinase		/	Unkown
HY-N0060S1	Ferulic acid-13C3	Inhibitor	98.3%	Unkown
HY-N9507	Picrasidine Q		/	Unkown
HY-RS04915	FGFR2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS04916	Fgfr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04917	Fgfr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-159503A	Segigratinib hydrochloride	Inhibitor	/	Unkown
HY-174689	Human FGFR2 mRNA		/	Unkown
HY-W754878	Pemigatinib-d6	Inhibitor	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99010A	Bemarituzumab (FUT8-KO)	Inhibitor	99.74%	Unkown
HY-141600	Aprutumab ixadotin		98.99%	Unkown
HY-P991584	HuGAL-FR21	Inhibitor	97.80%	Unkown
HY-P991583	GP369	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	FGFR2	NCBI	NCBI:2263

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