UBE2G1 - ubiquitin conjugating enzyme E2 G1 Gene

Also Known as UBC7; E217K; UBE2G

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7326

About UBE2G1

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,269,259-4,366,675 (from NCBI)

This gene has 6 transcripts (splice variants), 223 orthologues and 24 paralogues. Ubiquitous expression in esophagus (RPKM 18.3), lymph node (RPKM 16.3) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to Other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]

UBE2G1 Products (1)

mRNA	Protein	Name
NM_003342.5	NP_003333.1	ubiquitin-conjugating enzyme E2 G1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables ubiquitin conjugating enzyme activity	IDA IDA: Inferred from direct assay	14593114	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11439185	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	20061386	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	14593114	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2G1 Protein Structure

UQ_con

0
100
170 a.a.

Protein Preferred Names	Protein Names
ubiquitin-conjugating enzyme E2 G1	E2 ubiquitin-conjugating enzyme G1

UBE2G1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBE2G1	P62253	SH3GLB1	Homo sapiens	Q9Y371	Y2H Pooling	32814053
Intra	UBE2G1	P62253	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32814053
Intra	UBE2G1	P62253	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32814053
Intra	UBE2G1	P62253	GNB2	Homo sapiens	P62879	Y2H Pooling	32814053
Intra	UBE2G1	P62253	GNB2	Homo sapiens	P62879	Validated Y2H	32814053
Intra	UBE2G1	P62253	GNB2	Homo sapiens	P62879	Y2H Array	32814053
Intra	UBE2G1	P62253	CCK	Homo sapiens	P06307	Validated Y2H	32814053
Intra	UBE2G1	P62253	CCK	Homo sapiens	P06307	Y2H Pooling	32814053
Intra	UBE2G1	P62253	CCK	Homo sapiens	P06307	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2G1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77271	UBE2G1 Protein, Human	P62253 (M1-E170)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15346	UBE2G1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20614	Ube2g1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27122	Ube2g1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UBE2G1	MGD	MGI:1914378
Canis familiaris	UBE2G1	VGNC	VGNC:48052
Rattus norvegicus	UBE2G1	RGD	RGD:620392
Macaca mulatta	UBE2G1	VGNC	VGNC:78695
Felis catus	UBE2G1	VGNC	VGNC:66759
Bos taurus	UBE2G1	VGNC	VGNC:36581
Others	UBE2G1	NCBI