Syvn1 - synovial apoptosis inhibitor 1, synoviolin Gene

Also Known as Hrd1; 1200010C09Rik; D530017H19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74126

Summary

Enables ubiquitin protein Ligase activity. Involved in immature B cell differentiation; protein stabilization; and proteolysis involved in cellular protein catabolic process. Acts upstream of or within in utero embryonic development and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in endoplasmic reticulum quality control compartment. Is expressed in rib. Orthologous to human SYVN1 (synoviolin 1). [provided by Alliance of Genome Resources, Apr 2022]

Syvn1 Products (2)

mRNA Protein Name
NM_001164709.1 NP_001158181.1 E3 ubiquitin-protein ligase synoviolin
NM_028769.5 NP_083045.4 E3 ubiquitin-protein ligase synoviolin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19725872 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
21911472 MGI
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
29907570 MGI
Biological Process GO Annotation Evidence References Source
involved in ERAD pathway IDA
IDA: Inferred from direct assay
21454652 MGI
involved in immature B cell differentiation IMP
IMP: Inferred from mutant phenotype
29907570 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
15611074 MGI
acts upstream of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
15611074 MGI
acts upstream of or within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
15611074 MGI
involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
20160352 MGI
involved in protein stabilization IDA
IDA: Inferred from direct assay
21454652 MGI
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
21911472 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum quality control compartment IDA
IDA: Inferred from direct assay
17707796 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase synoviolin

  • RING-type E3 ubiquitin transferase synoviolin

  • synoviolin 1

Syvn1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Syvn1 Q9DBY1 Ncstn Mus musculus P57716
Anti Bait CoIP
19725872
Intra
Syvn1 Q9DBY1 Ncstn Mus musculus P57716
Anti Tag CoIP
19725872
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135844 LS-102 Inhibitor 97.89% Unkown
HY-RS14127 SYVN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-184455 PROTAC BRD4 Degrader-47 Degrader / Unkown
HY-184456 Clofibric acid-C-Ph-hexyne-C4-NH2 / Unkown
HY-184457 NH2-C-Ph-hexyne-C4-NH2 / Unkown
HY-RS18845 Syvn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25337 Syvn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syvn1 NCBI NCBI:84447