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Cat. No.: HY-184456

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Clofibric acid-C-Ph-hexyne-C4-NH2

Clofibric acid-C-Ph-hexyne-C4-NH2 is an E3 Ligase Ligand-Linker Conjugate that can be used in studies related to PROTAC synthesis, such as for PROTAC BRD4 Degrader-47 (HY-184455).

For research use only. We do not sell to patients.

Formula: C₂₃H₂₇ClN₂O₂
Molecular Weight:398.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Clofibric acid-C-Ph-hexyne-C4-NH2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Clofibric acid-C-Ph-hexyne-C4-NH2 is an E3 Ligase Ligand-Linker Conjugate that can be used in studies related to PROTAC synthesis, such as for PROTAC BRD4 Degrader-47 (HY-184455)^[1].

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

Clofibric acid-C-Ph-hexyne-C4-NH2 (compound 25) is an E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC BRD4 Degrader-47 (HY-184455). PROTAC BRD4 Degrader-47 selectively degrades BRD4 in a SYVN1-dependent manner, with a DC₅₀ of 0.93 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 398.93
Formula C₂₃H₂₇ClN₂O₂
SMILES

CC(C)(OC1=CC=C(Cl)C=C1)C(NCC2=CC=C(C#CCCCCN)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Warren J, et al. Identification of Clofibric Acid as a Synoviolin (SYVN1) Ligand for Proteolysis-Targeting Chimera (PROTAC) Development. ACS Medicinal Chemistry Letters. 2026.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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