Uvrag - UV radiation resistance associated gene Gene

Mus musculus

Also known as Uvrag1; Uvragl; 9530039D02Rik

Gene ID: 78610 | Gene type: protein coding

About Uvrag

Summary

Enables SH3 domain binding activity and SNARE binding activity. Involved in DNA repair; chromosome segregation; and microtubule Cytoskeleton organization. Acts upstream of or within SNARE complex assembly and viral entry into host cell. Located in phagocytic vesicle. Part of protein-containing complex. Is expressed in midgut; smooth muscle tissue; and thyroid gland. Orthologous to human UVRAG (UV radiation resistance associated). [provided by Alliance of Genome Resources, Apr 2022]

Uvrag Products(1)

mRNA	Protein	Name
NM_178635.3	NP_848750.3	UV radiation resistance-associated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	17891140	MGI
enables SNARE binding	IDA IDA: Inferred from direct assay	24550300	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17891140	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA repair	IMP IMP: Inferred from mutant phenotype	22542840	MGI
acts upstream of or within SNARE complex assembly	IMP IMP: Inferred from mutant phenotype	24550300	MGI
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	22542840	MGI
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	22542840	MGI
involved in spindle organization	IMP IMP: Inferred from mutant phenotype	22542840	MGI
acts upstream of or within symbiont entry into host cell	IMP IMP: Inferred from mutant phenotype	24550300	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in phagocytic vesicle	IPI IPI: Inferred from physical interaction	22493499	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	17891140	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

UV radiation resistance-associated protein

UV radiation resistance associated protein

UV radiation resistance-associated gene protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156237	Beclin1-ATG14L interaction inhibitor 1	Inhibitor	99.88%	Unkown
HY-152100	CUR5g	Inhibitor	98.69%	Unkown
HY-RS15588	UVRAG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Uvrag	NCBI	NCBI:7405

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