Grid2 - glutamate ionotropic receptor delta type subunit 2 Gene

Rattus norvegicus

Also known as GluD2

Gene ID: 79220 | Gene type: protein coding

About Grid2

Summary

Enables PDZ domain binding activity and identical protein binding activity. Involved in regulation of presynapse assembly. Located in postsynaptic density and postsynaptic membrane. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 18. Orthologous to human GRID2 (glutamate ionotropic receptor delta type subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Grid2 Products(1)

mRNA	Protein	Name
NM_024379.2	NP_077355.2	glutamate receptor ionotropic, delta-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	12589829	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	17715062	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	20395510	RGD
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	20395510	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	8987804	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20395510	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	8987804	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	8987804	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	8987804	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor ionotropic, delta-2

gluR delta-2 subunit

glutamate receptor delta-2 subunit

Grid2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Grid2	Q63226	Dlg2	Rattus norvegicus	Q63622	Crosslink	10234023
Intra	Grid2	Q63226	Dlg4	Rattus norvegicus	P31016	Y2H Array	10234023
Intra	Grid2	Q63226	Dlg2	Rattus norvegicus	Q63622	IF	10234023
Intra	Grid2	Q63226	Grid2	Rattus norvegicus	Q63226	Solution Sedimentation	19617541
Intra	Grid2	Q63226	Dlg2	Rattus norvegicus	Q63622	Anti Bait CoIP	10234023
Intra	Grid2	Q63226	Grid2	Rattus norvegicus	Q63226	X-Ray Diffraction	17715062
Intra	Grid2	Q63226	Dlg2	Rattus norvegicus	Q63622	EM	10234023

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05796	GRID2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grid2	NCBI	NCBI:2895

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