DLG2 - Dlg2 discs large MAGUK scaffold protein 2 Gene

Also Known as Dlgh2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64053

Summary

Enables PDZ domain binding activity; protein C-terminus binding activity; and protein Phosphatase binding activity. Involved in neuronal ion channel clustering and receptor clustering. Located in several cellular components, including dendrite; juxtaparanode region of axon; and neuronal cell body. Is active in glutamatergic synapse. Is anchored component of postsynaptic density membrane. Orthologous to human DLG2 (discs large MAGUK scaffold protein 2). [provided by Alliance of Genome Resources, Apr 2022]

DLG2 Products (1)

mRNA Protein Name
NM_022282.2 NP_071618.2 disks large homolog 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
15024025 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9786987 RGD
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
20410104 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
8755482 RGD
Biological Process GO Annotation Evidence References Source
involved in neuronal ion channel clustering IMP
IMP: Inferred from mutant phenotype
8755482 RGD
involved in receptor clustering IMP
IMP: Inferred from mutant phenotype
8755482 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
8755482 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10648730 RGD
located in juxtaparanode region of axon IDA
IDA: Inferred from direct assay
19109503 RGD
located in membrane IDA
IDA: Inferred from direct assay
20089912 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8755482 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
10648730 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
20089912 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disks large homolog 2

  • channel-associated protein of synapse-110

  • chapsyn-110

  • discs, large homolog 2

  • disks large 1 tumor suppressor protein-like

  • postsynaptic density protein PSD-93

  • synaptic density protein PSD-93

DLG2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Dlg2 Q63622 ATP2B4 Homo sapiens P23634-6
Anti Bait CoIP
11274188
Cross
Dlg2 Q63622 CRHR1 Homo sapiens P34998
Anti Tag CoIP
26352593
Cross
Dlg2 Q63622 KIF1B Homo sapiens O60333-3
Y2H
12097473
Intra
Dlg2 Q63622 Map1a Rattus norvegicus P34926
Pull Down
9786987
Intra
Dlg2 Q63622 Map1a Rattus norvegicus P34926
Far-WB
9786987
Intra
Dlg2 Q63622 Dgkz Rattus norvegicus O08560
Y2H
19229292
Intra
Dlg2 Q63622 Dgkz Rattus norvegicus O08560
Anti Bait CoIP
19229292
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03797 DLG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08623 MPP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19354 Mpp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25845 Mpp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens DLG2 NCBI NCBI:1740