FCRL2 - Fc receptor like 2 Gene

Also Known as FCRH2; IFGP4; IRTA4; SPAP1; CD307b; SPAP1A; SPAP1B; SPAP1C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79368

About FCRL2

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:157,745,733-157,777,132 (from NCBI)

This gene has 5 transcripts (splice variants), 42 orthologues and 17 paralogues. Biased expression in lymph node (RPKM 14.2), spleen (RPKM 13.1) and 7 other tissues.

Summary

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009]

FCRL2 Products (2)

mRNA Protein Name
NM_001159488.2 NP_001152960.1 Fc receptor-like protein 2 isoform 2 precursor
NM_030764.4 NP_110391.2 Fc receptor-like protein 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
11162587 GOA
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
11162587 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
16849395 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCRL2 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (23 - 102)

Ig_3

Ig_3: Immunoglobulin domain (108 - 180)

Ig_2

Ig_2: Immunoglobulin domain (208 - 292)

Ig_3

Ig_3: Immunoglobulin domain (299 - 372)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

Fc receptor-like protein 2

  • IFGP family protein 4

FCRL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FCRL2 Q96LA5 METAP2 Homo sapiens P50579
Anti Tag CoIP
28514442
Intra
FCRL2 Q96LA5 METAP2 Homo sapiens P50579
Anti Tag CoIP
33961781
Intra
FCRL2 Q96LA5 NCK2 Homo sapiens O43639
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FCRL2 Proteins

Cat. No. Product Name Accession Purity
HY-P76924 FCRL2 Protein, Human (HEK293, His, solution) Q96LA5-1/NP_110391.2 (L20-D395) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04843 FCRL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04849 FCRLB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22505 Fcrl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FCRL2 VGNC VGNC:107873
Mus musculus FCRL2 MGD MGI:1933397
Macaca mulatta FCRL2 VGNC VGNC:72509
Rattus norvegicus FCRL2 RGD RGD:1306885
Canis familiaris FCRL2 VGNC VGNC:55740
Others FCRL2 NCBI