2. Gene
  3. IL17RC - interleukin 17 receptor C Gene

IL17RC - interleukin 17 receptor C Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CANDF9; IL17RL; IL17-RL

Gene ID: 84818 | Gene type: protein coding

About IL17RC

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,917,098-9,933,621 (from NCBI)

This gene has 47 transcripts (splice variants), 127 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in prostate (RPKM 15.4), skin (RPKM 9.6) and 25 other tissues.

Summary

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

IL17RC Products(10)

mRNA Protein Name
NM_001203263.2 NP_001190192.2 interleukin-17 receptor C isoform 4 precursor
NM_001203264.2 NP_001190193.2 interleukin-17 receptor C isoform 5 precursor
NM_001203265.2 NP_001190194.2 interleukin-17 receptor C isoform 6 precursor
NM_001367278.1 NP_001354207.1 interleukin-17 receptor C isoform 7 precursor
NM_001367279.1 NP_001354208.1 interleukin-17 receptor C isoform 8 precursor
NM_001367280.1 NP_001354209.1 interleukin-17 receptor C isoform 9 precursor
NM_001410711.1 NP_001397640.1 interleukin-17 receptor C isoform 10 precursor
NM_032732.6 NP_116121.3 interleukin-17 receptor C isoform 3 precursor
NM_153460.4 NP_703190.2 interleukin-17 receptor C isoform 1 precursor
NM_153461.4 NP_703191.2 interleukin-17 receptor C isoform 2 precursor

IL17RC Protein Structure

IL17_R_N

IL17_R_N: Interleukin-17 receptor extracellular region (142 - 532)

SEFIR

SEFIR: SEFIR domain (585 - 737)

  • 0
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  • 791 a.a.
Protein Preferred Names Protein Names

interleukin-17 receptor C

IL-17 receptor C

Recombinant IL17RC Proteins

Cat. No. Product Name Accession Purity
HY-P72580 IL-17RC Protein, Human (434a.a, HEK293, Fc) Q8NAC3-3 (L21-A454) ≥95%
HY-P75837 IL-17RC Protein, Human (sf9, His) Q8NAC3-3 (M1-A454) ≥95%
HY-P75838 IL-17RC Protein, Human (454a.a, HEK293, Fc) Q8NAC3-3 (M1-A454) ≥95%

Related Diseases

Diseases Alias
Candidiasis, Familial, 9

CANDF9

Candidiasis, Familial, Type 9
Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous

Cmc

Candidiasis Chronic Mucocutaneous
Candidiasis

Systemic Candidiasis

Invasive Candidiasis

Disseminated Candidiasis

Systemic Candida Infections

Candidiasis, Invasive
Immunodeficiency 29

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12b Deficiency

IMD29

Il12b Deficiency

Immunodeficiency 29, Mycobacteriosis

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interleukin 12b Deficiency

Msmd Due To Complete Il12b Deficiency

Msmd Due To Complete Interleukin 12b Deficiency

Immunodeficiency, Type 29, Mycobacteriosis
Nail Disease

Nail Diseases

Abnormality Of The Nail

Nail Anomaly
Cutaneous Candidiasis

Candidiasis, Cutaneous
Hyper Ige Recurrent Infection Syndrome 1

Job Syndrome

Hyper-Ige Recurrent Infection Syndrome 1

Hyperimmunoglobulin E Syndrome

Job'S Syndrome

Recurring Cold Staphylococcal Abscesses

Ige Syndromes

Buckley Syndrome

Hie - [Hyperimmunoglobulin E] Syndrome

Job-Buckley Syndrome

Quie-Hill Syndrome
Macular Degeneration, Age-Related, 1

Macular Degeneration

Age-Related Macular Degeneration

Macular Degeneration, Age-Related

Age Related Macular Degeneration

Age Related Macular Degeneration 1

ARMD1

Senile Macular Degeneration

Maculopathy, Age-Related, 1

Macular Degeneration, Age-Related, Reduced Risk Of

Age Related Maculopathy 1

Age Related Maculopathies

Age Related Maculopathy

Senile Macular Retinal Degeneration

Macular Degeneration Of Retina

Age-Related Maculopathy

Amd

Armd

Age-Related Maculopathy, Susceptibility To

Maculopathy Age-Related

Macular Degeneration, Age-Related, 1, Susceptibility To

Maculopathy, Age-Related

Macular Degeneration, Age-Related, Type 1

Macular Degeneration, Age-Related, 2
Candidal Paronychia

Candidiasis Of Skin

Candidiasis Of Skin And Nails

Candidal Perionyxis
Phaeohyphomycosis

Infection By Dematiacious Fungi

Phaehyphomycosis

Phaeomycosis

Pheohyphomycosis

Infection By Dematiacious Fungi [Phaehyphomycosis]

Dematiaceous Fungal Infection
Oral Candidiasis

Thrush

Candidiasis Of Mouth

Oral Moniliasis

Thrush, Oral

Candidiasis, Oral

Oral Thrush

Candidiasis

Equine Thrush
Autoimmune Polyendocrine Syndrome Type 1

Whitaker Syndrome

Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy

Autoimmune Polyglandular Syndrome I

Polyglandular Type I Autoimmune Syndrome
Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses
Fungal Infectious Disease

Mycoses

Mycosis
Hyper Ige Syndrome

Hyper-Ige Syndrome

Hyper Immunoglobulin E Syndrome

Hies

Hyper-Ige Recurrent Infection Syndrome

Hyperimmunoglobulin E Syndrome

Hyper Ige

Job Syndrome

Hartnup Disease
Scoliosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06704 IL17RC Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IL17RC VGNC VGNC:30123
Macaca mulatta IL17RC VGNC VGNC:84164
Rattus norvegicus IL17RC RGD RGD:1306392
Mus musculus IL17RC MGD MGI:2159336
Felis catus IL17RC VGNC VGNC:62903
Canis familiaris IL17RC VGNC VGNC:41948
Others IL17RC NCBI