IL17RC - interleukin 17 receptor C Gene

Also Known as CANDF9; IL17RL; IL17-RL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84818

About IL17RC

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,917,098-9,933,621 (from NCBI)

This gene has 47 transcripts (splice variants), 127 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in prostate (RPKM 15.4), skin (RPKM 9.6) and 25 other tissues.

Summary

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

IL17RC Products (10)

mRNA Protein Name
NM_001203263.2 NP_001190192.2 interleukin-17 receptor C isoform 4 precursor
NM_001203264.2 NP_001190193.2 interleukin-17 receptor C isoform 5 precursor
NM_001203265.2 NP_001190194.2 interleukin-17 receptor C isoform 6 precursor
NM_001367278.1 NP_001354207.1 interleukin-17 receptor C isoform 7 precursor
NM_001367279.1 NP_001354208.1 interleukin-17 receptor C isoform 8 precursor
NM_001367280.1 NP_001354209.1 interleukin-17 receptor C isoform 9 precursor
NM_001410711.1 NP_001397640.1 interleukin-17 receptor C isoform 10 precursor
NM_032732.6 NP_116121.3 interleukin-17 receptor C isoform 3 precursor
NM_153460.4 NP_703190.2 interleukin-17 receptor C isoform 1 precursor
NM_153461.4 NP_703191.2 interleukin-17 receptor C isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables coreceptor activity IDA
IDA: Inferred from direct assay
20554964 GOA
enables interleukin-17 receptor activity IDA
IDA: Inferred from direct assay
17911633 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24120361 GOA
Biological Process GO Annotation Evidence References Source
involved in interleukin-17A-mediated signaling pathway IDA
IDA: Inferred from direct assay
20554964 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL17RC Protein Structure

IL17_R_N

IL17_R_N: Interleukin-17 receptor extracellular region (142 - 532)

SEFIR

SEFIR: SEFIR domain (585 - 737)

  • 0
  • 200
  • 400
  • 600
  • 791 a.a.
Protein Preferred Names Protein Names

interleukin-17 receptor C

  • IL-17 receptor C

Recombinant IL17RC Proteins

Cat. No. Product Name Accession Purity
HY-P72580 IL-17RC Protein, Human (HEK293, Fc) Q8NAC3-3 (L21-A454) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75837 IL-17RC Protein, Human (sf9, His) NP_116121.2 (M1-A454) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Candidiasis, Familial, 9

  • CANDF9

  • Candidiasis, Familial, Type 9
Chronic Mucocutaneous Candidiasis

  • Candidiasis, Chronic Mucocutaneous

  • Cmc

  • Candidiasis Chronic Mucocutaneous
Candidiasis

  • Systemic Candidiasis

  • Invasive Candidiasis

  • Disseminated Candidiasis

  • Systemic Candida Infections

  • Candidiasis, Invasive
Immunodeficiency 29

  • Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12b Deficiency

  • IMD29

  • Il12b Deficiency

  • Immunodeficiency 29, Mycobacteriosis

  • Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interleukin 12b Deficiency

  • Msmd Due To Complete Il12b Deficiency

  • Msmd Due To Complete Interleukin 12b Deficiency

  • Immunodeficiency, Type 29, Mycobacteriosis
Nail Disease

  • Nail Diseases

  • Abnormality Of The Nail

  • Nail Anomaly
Cutaneous Candidiasis

  • Candidiasis, Cutaneous
Hyper Ige Recurrent Infection Syndrome 1

  • Job Syndrome

  • Hyper-Ige Recurrent Infection Syndrome 1

  • Hyperimmunoglobulin E Syndrome

  • Job'S Syndrome

  • Recurring Cold Staphylococcal Abscesses

  • Ige Syndromes

  • Buckley Syndrome

  • Hie - [Hyperimmunoglobulin E] Syndrome

  • Job-Buckley Syndrome

  • Quie-Hill Syndrome
Macular Degeneration, Age-Related, 1

  • Macular Degeneration

  • Age-Related Macular Degeneration

  • Macular Degeneration, Age-Related

  • Age Related Macular Degeneration

  • Age Related Macular Degeneration 1

  • ARMD1

  • Senile Macular Degeneration

  • Maculopathy, Age-Related, 1

  • Macular Degeneration, Age-Related, Reduced Risk Of

  • Age Related Maculopathy 1

  • Age Related Maculopathies

  • Age Related Maculopathy

  • Senile Macular Retinal Degeneration

  • Macular Degeneration Of Retina

  • Age-Related Maculopathy

  • Amd

  • Armd

  • Age-Related Maculopathy, Susceptibility To

  • Maculopathy Age-Related

  • Macular Degeneration, Age-Related, 1, Susceptibility To

  • Maculopathy, Age-Related

  • Macular Degeneration, Age-Related, Type 1

  • Macular Degeneration, Age-Related, 2
Candidal Paronychia

  • Candidiasis Of Skin

  • Candidiasis Of Skin And Nails

  • Candidal Perionyxis
Phaeohyphomycosis

  • Infection By Dematiacious Fungi

  • Phaehyphomycosis

  • Phaeomycosis

  • Pheohyphomycosis

  • Infection By Dematiacious Fungi [Phaehyphomycosis]

  • Dematiaceous Fungal Infection
Oral Candidiasis

  • Thrush

  • Candidiasis Of Mouth

  • Oral Moniliasis

  • Thrush, Oral

  • Candidiasis, Oral

  • Oral Thrush

  • Candidiasis

  • Equine Thrush
Autoimmune Polyendocrine Syndrome Type 1

  • Whitaker Syndrome

  • Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy

  • Autoimmune Polyglandular Syndrome I

  • Polyglandular Type I Autoimmune Syndrome
Opportunistic Mycosis

  • Opportunistic Mycoses

  • Opportunistic Systemic Mycoses
Fungal Infectious Disease

  • Mycoses

  • Mycosis
Hyper Ige Syndrome

  • Hyper-Ige Syndrome

  • Hyper Immunoglobulin E Syndrome

  • Hies

  • Hyper-Ige Recurrent Infection Syndrome

  • Hyperimmunoglobulin E Syndrome

  • Hyper Ige

  • Job Syndrome

  • Hartnup Disease
Scoliosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06704 IL17RC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21141 Il17rc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27658 Il17rc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IL17RC VGNC VGNC:30123
Macaca mulatta IL17RC VGNC VGNC:84164
Rattus norvegicus IL17RC RGD RGD:1306392
Mus musculus IL17RC MGD MGI:2159336
Felis catus IL17RC VGNC VGNC:62903
Canis familiaris IL17RC VGNC VGNC:41948
Others IL17RC NCBI