Vamp7 - vesicle-associated membrane protein 7 Gene

Rattus norvegicus

Also known as Sybl1

Gene ID: 85491 | Gene type: protein coding

About Vamp7

Summary

Enables SNAP receptor activity and syntaxin binding activity. Involved in several processes, including Golgi vesicle transport; regulated exocytosis; and triglyceride transport. Located in several cellular components, including cytoplasmic vesicle; filopodium; and lysosomal membrane. Part of SNARE complex. Is active in hippocampal mossy fiber to CA3 synapse. Is integral component of synaptic vesicle membrane. Orthologous to human VAMP7 (vesicle associated membrane protein 7). [provided by Alliance of Genome Resources, Apr 2022]

Vamp7 Products(1)

mRNA	Protein	Name
NM_053531.2	NP_445983.1	vesicle-associated membrane protein 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNAP receptor activity	IDA IDA: Inferred from direct assay	15133481	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19745841	RGD
enables syntaxin binding	IPI IPI: Inferred from physical interaction	15133481	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium-ion regulated exocytosis	IDA IDA: Inferred from direct assay	14993220	RGD
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA IDA: Inferred from direct assay	16495485	RGD
involved in endosome to lysosome transport	IDA IDA: Inferred from direct assay	15133481	RGD
involved in eosinophil degranulation	IDA IDA: Inferred from direct assay	14993220	RGD
involved in exocytosis	IDA IDA: Inferred from direct assay	22705394	RGD
involved in neutrophil degranulation	IDA IDA: Inferred from direct assay	14993220	RGD
involved in phagocytosis, engulfment	IDA IDA: Inferred from direct assay	15133481	RGD
involved in synaptic vesicle exocytosis	EXP EXP: Inferred from Experiment	24210904	RGD
involved in synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	24210904	RGD
involved in synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	24210904	RGD
involved in triglyceride transport	IMP IMP: Inferred from mutant phenotype	16495485	RGD
involved in vesicle fusion	IDA IDA: Inferred from direct assay	15133481	RGD
involved in vesicle fusion with Golgi apparatus	IDA IDA: Inferred from direct assay	16735505	RGD
involved in vesicle transport along microtubule	IDA IDA: Inferred from direct assay	22705394	RGD
involved in vesicle-mediated transport	IDA IDA: Inferred from direct assay	15133481	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	15133481	RGD
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	16495485	RGD
located in filopodium	IDA IDA: Inferred from direct assay	19745841	RGD
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	14596849	RGD
located in late endosome membrane	IDA IDA: Inferred from direct assay	10459012	RGD
located in lysosomal membrane	IDA IDA: Inferred from direct assay	10459012	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	19745841	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19745841	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	14596849	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicle-associated membrane protein 7

VAMP-7	synaptobrevin-like 1
synaptobrevin-like protein 1

Vamp7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Vamp7	Q9JHW5	ANKRD27	Homo sapiens	Q96NW4	Y2H	19745841
Cross	Vamp7	Q9JHW5	ANKRD27	Homo sapiens	Q96NW4	Anti Bait CoIP	19745841
Cross	Vamp7	Q9JHW5	ANKRD27	Homo sapiens	Q96NW4	Pull Down	19745841

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P10809	VAMP	Inhibitor	98.13%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15598	VAMP7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vamp7	NCBI	NCBI:6845

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