Vamp7 - vesicle-associated membrane protein 7 Gene

Also Known as Sybl1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85491

Summary

Enables SNAP receptor activity and syntaxin binding activity. Involved in several processes, including Golgi vesicle transport; regulated exocytosis; and triglyceride transport. Located in several cellular components, including cytoplasmic vesicle; filopodium; and lysosomal membrane. Part of SNARE complex. Is active in hippocampal mossy fiber to CA3 synapse. Is integral component of synaptic vesicle membrane. Orthologous to human VAMP7 (vesicle associated membrane protein 7). [provided by Alliance of Genome Resources, Apr 2022]

Vamp7 Products (1)

mRNA Protein Name
NM_053531.2 NP_445983.1 vesicle-associated membrane protein 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNAP receptor activity IDA
IDA: Inferred from direct assay
15133481 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19745841 RGD
enables syntaxin binding IPI
IPI: Inferred from physical interaction
15133481 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium-ion regulated exocytosis IDA
IDA: Inferred from direct assay
14993220 RGD
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
IDA: Inferred from direct assay
16495485 RGD
involved in endosome to lysosome transport IDA
IDA: Inferred from direct assay
15133481 RGD
involved in eosinophil degranulation IDA
IDA: Inferred from direct assay
14993220 RGD
involved in exocytosis IDA
IDA: Inferred from direct assay
22705394 RGD
involved in neutrophil degranulation IDA
IDA: Inferred from direct assay
14993220 RGD
involved in phagocytosis, engulfment IDA
IDA: Inferred from direct assay
15133481 RGD
involved in synaptic vesicle exocytosis EXP
EXP: Inferred from Experiment
24210904 RGD
involved in synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
24210904 RGD
involved in synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
24210904 RGD
involved in triglyceride transport IMP
IMP: Inferred from mutant phenotype
16495485 RGD
involved in vesicle fusion IDA
IDA: Inferred from direct assay
15133481 RGD
involved in vesicle fusion with Golgi apparatus IDA
IDA: Inferred from direct assay
16735505 RGD
involved in vesicle transport along microtubule IDA
IDA: Inferred from direct assay
22705394 RGD
involved in vesicle-mediated transport IDA
IDA: Inferred from direct assay
15133481 RGD
Cellular Component GO Annotation Evidence References Source
part of SNARE complex IDA
IDA: Inferred from direct assay
15133481 RGD
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
16495485 RGD
located in filopodium IDA
IDA: Inferred from direct assay
19745841 RGD
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
14596849 RGD
located in late endosome membrane IDA
IDA: Inferred from direct assay
10459012 RGD
located in lysosomal membrane IDA
IDA: Inferred from direct assay
10459012 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
19745841 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19745841 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
14596849 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicle-associated membrane protein 7

  • VAMP-7

  • synaptobrevin-like 1

  • synaptobrevin-like protein 1

Vamp7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Vamp7 Q9JHW5 ANKRD27 Homo sapiens Q96NW4
Y2H
19745841
Cross
Vamp7 Q9JHW5 ANKRD27 Homo sapiens Q96NW4
Anti Bait CoIP
19745841
Cross
Vamp7 Q9JHW5 ANKRD27 Homo sapiens Q96NW4
Pull Down
19745841
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10809 VAMP Inhibitor 98.13% Phase 2

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15598 VAMP7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vamp7 NCBI NCBI:6845