HRK - harakiri, BCL2 interacting protein Gene

Also Known as DP5; HARAKIRI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8739

About HRK

Cytogenetic location: 12q24.22 Genomic coordinates (GRCh38): 12:116,856,144-116,881,441 (from NCBI)

This gene has 4 transcripts (splice variants) and 54 orthologues. Biased expression in brain (RPKM 5.1), thyroid (RPKM 2.9) and 3 other tissues.

Summary

This gene encodes a member of the Bcl-2 protein family. Members of this family are involved in activating or inhibiting Apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes Apoptosis by interacting with the apoptotic inhibitors Bcl-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

HRK Products (1)

mRNA Protein Name
NM_003806.4 NP_003797.1 activator of apoptosis harakiri

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14596824 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15031724 GOA
involved in positive regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
21041309 GOA
involved in positive regulation of release of cytochrome c from mitochondria IDA
IDA: Inferred from direct assay
21041309 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
15031724 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HRK Protein Structure

Harakiri

Harakiri: Activator of apoptosis harakiri (1 - 91)

  • 0
  • 91 a.a.
Protein Preferred Names Protein Names

activator of apoptosis harakiri

  • BH3-interacting domain-containing protein 3

HRK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HRK O00198 BCL2L1 Homo sapiens Q07817-1
SPR
15694340
Intra
HRK O00198 BCL2L1 Homo sapiens Q07817-1
Y2H
15031724
Intra
HRK O00198 C1QBP Homo sapiens Q07021
Y2H
15031724
Intra
HRK O00198 C1QBP Homo sapiens Q07021
Pull Down
15031724
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chronic Gonococcal Salpingitis

  • Gonococcal Salpingitis
Cycloplegia

  • Ciliary Muscle Paresis

  • Cycloplegic Paralysis Of Accommodation

  • Paresis Of Accommodation

  • Visual Accommodation Paralysis

  • Accommodation Paralysis

  • Intrinsic Paralysis Of Eye Muscle

  • Cycloplegic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1576A AMARA peptide TFA Substrate 98.53% Unkown
HY-P5342 Hrk BH3 99.74% Unkown
HY-180948 PZ-11 Inducer / Unkown
HY-P1576 AMARA peptide Substrate / Unkown
HY-RS06371 HRK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21284 Hrk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27803 Hrk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HRK VGNC VGNC:107709
Mus musculus HRK MGD MGI:1201608
Rattus norvegicus HRK RGD RGD:70549
Canis familiaris HRK VGNC VGNC:41789
Bos taurus HRK VGNC VGNC:29957
Others HRK NCBI