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VNN2 - vanin 2 Gene

Also Known as FOAP-4; GPI-80

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8875

About VNN2

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:132,743,870-132,763,455 (from NCBI)

This gene has 16 transcripts (splice variants), 127 orthologues and 2 paralogues. Biased expression in spleen (RPKM 12.9), lymph node (RPKM 11.0) and 11 other tissues.

Summary

This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each Other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess Pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two Other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

VNN2 Products (3)

mRNA	Protein	Name
NM_001242350.3	NP_001229279.2	pantetheine hydrolase VNN2 isoform 3 precursor
NM_004665.6	NP_004656.3	pantetheine hydrolase VNN2 isoform 1 precursor
NM_078488.3	NP_511043.2	pantetheine hydrolase VNN2 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables pantetheine hydrolase activity	IDA IDA: Inferred from direct assay	11491533	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in pantothenate metabolic process	IDA IDA: Inferred from direct assay	11491533	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VNN2 Protein Structure

CN_hydrolase

0
100
200
300
400
520 a.a.

Protein Preferred Names	Protein Names
pantetheine hydrolase VNN2	Vannin 2

VNN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VNN2	O95498	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	VNN2	O95498	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	VNN2	O95498	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	VNN2	O95498	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	VNN2	O95498	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	VNN2	O95498	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VNN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71045	VNN2/Vanin-2 Protein, Human (HEK293, His)	O95498-1 (Q23-S492)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Trichuriasis	Whipworm Infection Whipworm Disease Trichocephaliasis Infection By Trichuris Trichura Trichuriasis Infection Trichuris Trichiura Infection Infection By Trichuris Trichiura Trichocephalosis Infection By Trichocephalus Trichiura Infection By Trichuris Infection By Trichuris Trichiuria Trichuriosis Whipworm Infection Due To Trichuris Trichiura Trichocephalus Infestation Trichuris Infestation Whipworm Infestation
Localized Chondrosarcoma
Biotin Deficiency	Biotin Deficiency Disease B7 Deficiency Biotan Vitamin Deficiency
Cystinosis	Cystine Storage Disease Cystine Diathesis Cystine Disease Cystinoses Protein Defect Of Cystin Transport Cystin Transport, Protein Defect Of Nephropathic Cystinosis Protein Defect Of Cystine Transport

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15667	VNN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown