Trpc6 - transient receptor potential cation channel, subfamily C, member 6 Gene

Also Known as Trrp6

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 89823

Summary

Enables several functions, including ATPase binding activity; clathrin binding activity; and cytoskeletal protein binding activity. Involved in several processes, including cellular response to hydrogen peroxide; generation of neurons; and positive regulation of peptidyl-threonine phosphorylation. Located in plasma membrane. Used to study focal segmental glomerulosclerosis; kidney disease; and transient cerebral ischemia. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in chronic fatigue syndrome; focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6). [provided by Alliance of Genome Resources, Apr 2022]

Trpc6 Products (1)

mRNA Protein Name
NM_053559.1 NP_446011.1 short transient receptor potential channel 6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATPase binding IPI
IPI: Inferred from physical interaction
16025302 RGD
enables actin binding IDA
IDA: Inferred from direct assay
16025302 RGD
enables actinin binding IDA
IDA: Inferred from direct assay
16025302 RGD
enables calcium channel activity IDA
IDA: Inferred from direct assay
20501650 RGD
enables clathrin binding IDA
IDA: Inferred from direct assay
16025302 RGD
enables monoatomic cation channel activity IDA
IDA: Inferred from direct assay
11278449 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16025302 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
20501650 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
19889962 RGD
involved in negative regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
22764246 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
20479868 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
11788346 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
22764246 RGD
involved in positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
20479868 RGD
involved in positive regulation of peptidyl-threonine phosphorylation IMP
IMP: Inferred from mutant phenotype
22699894 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

short transient receptor potential channel 6

  • transient receptor protein 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101795 Larixyl acetate Inhibitor 99.44% Unkown
HY-161766 L687 Activator 99.49% Unkown
HY-179490 AM-0883 Agonist 99.67% Unkown
HY-162090 TRPC antagonist 1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpc6 NCBI NCBI:7225