TRPC6 - transient receptor potential cation channel subfamily C member 6 Gene

Also Known as TRP6; FSGS2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7225

About TRPC6

Cytogenetic location: 11q22.1 Genomic coordinates (GRCh38): 11:101,451,564-101,584,007 (from NCBI)

This gene has 7 transcripts (splice variants), 264 orthologues, 5 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 7.7), lung (RPKM 7.3) and 18 other tissues.

Summary

The protein encoded by this gene forms a receptor-activated Calcium Channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]

TRPC6 Products (1)

mRNA	Protein	Name
NM_004621.6	NP_004612.2	short transient receptor potential channel 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables inositol 1,4,5 trisphosphate binding	IDA IDA: Inferred from direct assay	14505576	GOA
enables monoatomic cation channel activity	IDA IDA: Inferred from direct assay	19936226	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15757897	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	23291369	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within positive regulation of calcium ion transport	IDA IDA: Inferred from direct assay	10998353	GOA
acts upstream of or within positive regulation of ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	10998353	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23171048	GOA
located in membrane	IDA IDA: Inferred from direct assay	23171048	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10998353	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPC6 Protein Structure

Ank_2

TRP_2

Ion_trans

0
200
400
600
800
931 a.a.

Protein Preferred Names	Protein Names
short transient receptor potential channel 6	TRP-6

TRPC6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRPC6	Q9Y210	MX1	Homo sapiens	P20591	Pull Down	15757897
Intra	TRPC6	Q9Y210	MX1	Homo sapiens	P20591	Anti Tag CoIP	15757897
Intra	TRPC6	Q9Y210	MX1	Homo sapiens	P20591	Y2H	15757897

Cross: Cross-species interaction Intra: Intraspecies interaction

TRPC6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89598	TRPC6 Antibody (YA8942)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
Focal Segmental Glomerulosclerosis 2	FSGS2 Glomerulosclerosis, Focal Segmental, 2 Glomerulosclerosis, Segmental, Focal, Type 2
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Genetic Steroid-Resistant Nephrotic Syndrome	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Genetic Srns Hereditary Steroid-Resistant Nephrotic Syndrome Familial Idiopathic Nephrotic Syndrome Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive Srn1
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Hypothalamic Neoplasm	Hypothalamic Neoplasms Neoplasm Of The Hypothalamus Tumor Of Hypothalamus
Diencephalic Neoplasm	Malignant Diencephalic Neoplasm Malignant Diencephalic Tumor Tumor Of Diencephalon
Pyloric Stenosis
End Stage Renal Disease	End Stage Renal Failure End-Stage Kidney Disease Kidney Failure, Chronic Chronic Kidney Disease Stage 5
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Familial Nephrotic Syndrome	Congenital Nephrotic Syndrome Nephrosis, Congenital Finnish Congenital Nephrotic Syndrome
Focal Segmental Glomerulosclerosis 5	FSGS5 Glomerulosclerosis, Focal Segmental, 5 Glomerulosclerosis, Segmental, Focal, Type 5
Glomerulonephritis	Bright'S Disease
Progressive Familial Heart Block	Hereditary Bundle Branch Defect Hereditary Bundle Branch System Defect Familial Lenegre Disease Familial Lev Disease Familial Lev-Lenegre Disease Familial Pccd Familial Progressive Heart Block Pfhb Bundle Branch Block Hbbd Lenegre Lev Disease Lev Syndrome Lev'S Disease Lev-Lenègre Disease Pccd Progressive Cardiac Conduction Defect Bundle-Branch Block
Frasier Syndrome	FS
Lipoid Nephrosis	Minimal Change Disease Minimal Change Glomerulonephritis Nephrotic Syndrome With Lesion Of Minimal Change Glomerulonephritis Nephrotic Syndrome With Lesion Of Minimal Change Nephrotic Syndrome Idiopathic Minimal Change Nephrotic Syndrome Mcns Minimal Change Glomerulopathy Minimal Change Nephrotic Syndrome Nephrotic Syndrome Minimal Change Nephrosis, Lipoid Glomerulonephritis, Minimal Change Nephrotic Syndrome, Minimal Change
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques	Olmsted Syndrome Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques Palmoplantar And Periorificial Keratoderma Olms
Immunodeficiency 10	Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2 Combined Immunodeficiency Due To Stim1 Deficiency IMD10 Stim1 Deficiency Cid Due To Stim1 Deficiency Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2 Immunodeficiency, Type 10
Denys-Drash Syndrome	Drash Syndrome DDS Nephropathy, Wilms Tumor, And Genital Anomalies Wilms Tumor And Pseudohermaphroditism Wilms Tumor And Pseudo- Or True Hermaphroditism Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor Wilms Tumor-Dsd Syndrome Wilms Tumor-Disorder Of Sex Development Syndrome
Autoimmune Glomerulonephritis
T Cell And Nk Cell Immunodeficiency
Nail-Patella Syndrome	Turner-Kieser Syndrome Onychoosteodysplasia Fong Disease NPS Hereditary Onycho-Osteodysplasia Nps1 Hereditary Onychoostedysplasia Iliac Horn Syndrome Nail Patella Syndrome Turner-Kiser Syndrome Arthro-Onychodysplasia Nps 1 Osteo-Onychodysplasia Hereditary Osteo-Onychodysplasia Osterreicher Syndrome Pelvic Horn Syndrome Österreicher-Turner Syndrome Nps - [Nail-Patella Syndrome] Hood - [Hereditary Onycho-Osteodysplasia] Syndrome
Familial Episodic Pain Syndrome	Feps
Hypertrophic Pyloric Stenosis	Congenital Hypertrophic Pyloric Stenosis Pyloric Stenosis, Hypertrophic Congenital Or Infantile Stricture Of Pylorus Achalasia Of The Pylorus Congenital Hypertrophy Of The Pylorus Infantile Hypertrophy Of The Pylorus Infantile Constriction Of The Pylorus Congenital Stenosis Of The Pylorus Congenital Constriction Of The Pylorus Congenital Stricture Of The Pylorus Infantile Hypertrophic Pyloric Stenosis Infantile Stenosis Of The Pylorus Infantile Stricture Of The Pylorus Congenital Or Infantile Constriction Of Pylorus Infantile Pyloric Obstruction Infantile Pyloric Hypertrophy Pylorus Achalasia Pyloric Constriction Infantile Pyloric Stricture Infantile Pyloric Stenosis Congenital Spasm Of Pylorus Congenital Pylorospasm Congenital Pyloric Stricture Congenital Pyloric Spasm Congenital Or Infantile Spasm Of Pylorus Congenital Or Infantile Obstruction Of Pylorus Congenital Pyloric Stenosis
Retinitis Pigmentosa 36	RP36 Retinitis Pigmentosa-36 Retinitis Pigmentosa, Type 36
Alport Syndrome	Hereditary Nephritis Alport Syndrome, X-Linked Hemorrhagic Hereditary Nephritis Congenital Hereditary Hematuria Hemorrhagic Familial Nephritis Familial Nephritis Thin Basement Membrane Disease Thin Basement Membrane Nephropathy Hematuria-Nephropathy-Deafness Syndrome Hematuric Hereditary Nephritis Hereditary Familial Congenital Hemorrhagic Nephritis Hereditary Hematuria Syndrome Hereditary Interstitial Pyelonephritis Alport Deafness-Nephropathy Alport Hearing Loss-Nephropathy Alports Syndrome Nephritis, Hereditary
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Galloway-Mowat Syndrome	Galloway Mowat Syndrome Galloway Syndrome Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type Microcephaly Nephrosis Syndrome Microcephaly, Hiatal Hernia, And Nephrotic Syndrome Nephrosis Neuronal Dysmigration Syndrome Microcephaly-Hiatus Hernia-Nephrotic Syndrome Nephrosis-Neuronal Dysmigration Syndrome
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101795	Larixyl acetate	Inhibitor	99.44%	Unkown
HY-161766	L687	Activator	99.49%	Unkown
HY-179490	AM-0883	Agonist	99.67%	Unkown
HY-162090	TRPC antagonist 1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRPC6	VGNC	VGNC:36386
Felis catus	TRPC6	VGNC	VGNC:66586
Macaca mulatta	TRPC6	VGNC	VGNC:78654
Rattus norvegicus	TRPC6	RGD	RGD:619788
Canis familiaris	TRPC6	VGNC	VGNC:47871
Mus musculus	TRPC6	MGD	MGI:109523
Others	TRPC6	NCBI