TRPC6 Antibody (YA8942)
(Synonyms: TRP6, TRPC6, Short transient receptor potential channel 6, TrpC6, Transient receptor protein 6, TRP-6)
Based on 1 Customer Validation
TRPC6 Antibody (YA8942) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRPC6.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, ICC/IF, IF-Tissue, IP, ELISA
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Reactivity :
human, mouse, rat
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Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IP
IP: Immunoprecipitation
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|---|
| Dilution Ratio | 1:100-1000 | 1:50-500 | 1:50-500 | 1-2μg per 100-500μg Total protein | 1:30-3000 |
Product Details
TRPC6 Antibody (YA8942) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRPC6.
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Host Mouse
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Species Reactivityhuman, mouse, rat
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Calculated Molecular Weight Predicted band size: 106 kDa
OMIM: 603965
A synthesized peptide derived from human TRPC6.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
TRPC6 is a Non-selective, calcium-permeable cation channel. Mediates calcium entry following G(q)-coupled receptor or receptor tyrosine kinase activation, which triggers phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositides and production of diacylglycerol (DAG) that directly activates TRPC6. Does not appear to be activated by depletion of intracellular calcium stores. Mediates depolarization of intrinsically photosensitive retinal ganglion cells (ipRGCs) in response to light-induced melanopsin (OPN4)-mediated phototransduction via G(q)-PLC signaling, likely by forming heteromeric TRPC6-TRPC7 channels (By similarity)[1][2][3][4].
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. -
Isoforms & Post-Translational Modification
TRPC6 has 3 isoforms, Q9Y210-1: amino acid length is 931, molecular weight is 106326 Da (predicted); Q9Y210-2: amino acid length is 815, molecular weight is 93187 Da (predicted); Q9Y210-3: amino acid length is 876, molecular weight is 100106 Da (predicted).Phosphorylated by FYN, leading to an increase of TRPC6 channel activity
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Subunit
Homodimer; forms channel complex.
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SwissProt ID
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Synonyms
TRP6, TRPC6, Short transient receptor potential channel 6, TrpC6, Transient receptor protein 6, TRP-6
Documentation
[1]. Heeringa SF, et al. A novel TRPC6 mutation that causes childhood FSGS. PLoS One. 2009 Nov 10;4(11):e7771. [Content Brief]
[2]. Hofstra JM, et al. New TRPC6 gain-of-function mutation in a non-consanguineous Dutch family with late-onset focal segmental glomerulosclerosis. Nephrol Dial Transplant. 2013 Jul;28(7):1830-8. [Content Brief]
[3]. Riehle M, et al. TRPC6 G757D Loss-of-Function Mutation Associates with FSGS. J Am Soc Nephrol. 2016 Sep;27(9):2771-83. [Content Brief]
[4]. Hofmann T, et al. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63. [Content Brief]
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