AM-0883
Based on 1 Customer Validation
AM-0883 is a TRPC6 (Transient receptor potential canonical 6) agonist (hTRPC6 EC50 = 46 nM). AM-0083 can be used for the study of cardiac and renal diseases.
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- Pureté: 98.94%
- Formule: C21H21ClN2O3
- Masse moléculaire:384.86
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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hTRPC6 46 nM (EC50) |
AM-0883 can activate HEK293T cells WT TRPC6 (EC50 = 45.5 nM) and HEK293T N-terminal truncation mutant TRPC6 (Δ2–72) (EC50 = 90.2 nM)[1].
AM-0883 functionally activates the channel through specific residues at the S6/pore helix junction[1].
AM-0883 shows a significantly stronger activating effect on the V867T/L868T double mutant than on the wild-type channel[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Masse moléculaire 384.86
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Formule C21H21ClN2O3
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Color White to off-white
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SMILES
O=C(N1CCC2(C(C=C(Cl)C=C3)=C3NC2)CC1)[C@@H]4OC5=CC=CC=C5OC4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureté et documentation
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Fiche technique (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Bai Y, et al. Structural basis for pharmacological modulation of the TRPC6 channel. Elife. 2020 Mar 9;9:e53311. [Content Brief]
[2]. Chubanov V, et al. Physiological functions and pharmacological targeting of transient receptor potential channels. Pharmacol Rev. 2025 Nov;77(6):100089. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AM-0883 Related Classifications
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