Hmgb2 - high mobility group box 2 Gene

Also Known as Hmg2; HMG-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 97165

Summary

Enables cis-regulatory region sequence-specific DNA binding activity and protein domain specific binding activity. Involved in several processes, including regulation of gene expression; regulation of stem cell proliferation; and response to lipopolysaccharide. Acts upstream of or within several processes, including male gonad development; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and spermatid nucleus differentiation. Located in several cellular components, including chromatin; extracellular space; and nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; retina; and urinary system. Orthologous to human HMGB2 (high mobility group box 2). [provided by Alliance of Genome Resources, Apr 2022]

Hmgb2 Products (4)

mRNA Protein Name
NM_001363443.1 NP_001350372.1 high mobility group protein B2
NM_001363444.1 NP_001350373.1 high mobility group protein B2
NM_001363445.1 NP_001350374.1 high mobility group protein B2
NM_008252.3 NP_032278.1 high mobility group protein B2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
33795231 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23495099 MGI
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
19890330 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19805379 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
7720710 MGI
enables transcription factor binding IDA
IDA: Inferred from direct assay
23495099 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
19139395 MGI
involved in inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
25306442 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
11262228 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
19139395 MGI
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
23495099 MGI
acts upstream of or within positive regulation of DNA binding IDA
IDA: Inferred from direct assay
7720710 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
23495099 MGI
involved in positive regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
19890330 MGI
involved in positive regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
19890330 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11262228 MGI
involved in regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
24391977 MGI
involved in regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
24391977 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7720710 MGI
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
25306442 MGI
acts upstream of or within response to steroid hormone IMP
IMP: Inferred from mutant phenotype
11262228 MGI
acts upstream of or within spermatid nucleus differentiation IMP
IMP: Inferred from mutant phenotype
16765935 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
11262228 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
23495099 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
25306442 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
25306442 MGI
located in nucleus IDA
IDA: Inferred from direct assay
25306442 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

high mobility group protein B2

  • high mobility group protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-113772 Inflachromene Inhibitor 99.76% Unkown
HY-P10997 F3 peptide / Unkown
HY-RS06233 HMGB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16794 Hmgb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23235 Hmgb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmgb2 NCBI NCBI:3148