HMGB2 - high mobility group box 2 Gene

Also Known as HMG2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3148

About HMGB2

Cytogenetic location: 4q34.1 Genomic coordinates (GRCh38): 4:173,331,376-173,334,358 (from NCBI)

This gene has 5 transcripts (splice variants), 262 orthologues and 20 paralogues. Biased expression in bone marrow (RPKM 603.0), lymph node (RPKM 141.8) and 10 other tissues.

Summary

This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]

HMGB2 Products (3)

mRNA	Protein	Name
NM_001130688.1	NP_001124160.1	high mobility group protein B2
NM_001130689.1	NP_001124161.1	high mobility group protein B2
NM_002129.4	NP_002120.1	high mobility group protein B2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA binding	IMP IMP: Inferred from mutant phenotype	11909973	GOA
enables DNA binding, bending	IDA IDA: Inferred from direct assay	8339930	GOA
enables RAGE receptor binding	IGI IGI: Inferred from genetic interaction	19811285	GOA
enables chemoattractant activity	IDA IDA: Inferred from direct assay	19811285	GOA
enables damaged DNA binding	IDA IDA: Inferred from direct assay	8226934	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9636147	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19965638	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	19223331	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cell chemotaxis	IDA IDA: Inferred from direct assay	19811285	GOA
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19811285	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	23877675	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	23877675	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9636147	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11748232	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19965638	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	19811285	GOA
involved in positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	19965638	GOA
involved in positive regulation of megakaryocyte differentiation	IMP IMP: Inferred from mutant phenotype	19965638	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19223331	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7797075	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in condensed chromosome	IDA IDA: Inferred from direct assay	12925773	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11909973	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	19811285	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8339930	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	9010268	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	11909973	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMGB2 Protein Structure

HMG_box_2

HMG_box

0
100
209 a.a.

Protein Preferred Names	Protein Names
high mobility group protein B2	HMG-2

HMGB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	HMGB2	P26583	PKNOX1	Homo sapiens	Q96I87	Validated Y2H	25416956
Intra	HMGB2	P26583	PKNOX1	Homo sapiens	Q96I87	Y2H Array	25416956
Intra	HMGB2	P26583	PKNOX1	Homo sapiens	P55347	Y2H Array	31515488
Intra	HMGB2	P26583	PKNOX1	Homo sapiens	P55347	Validated Y2H	32296183
Intra	HMGB2	P26583	PKNOX1	Homo sapiens	P55347	Y2H Array	32296183
Intra	HMGB2	P26583	COMMD1	Homo sapiens	Q8N668	Y2H	31694235
Intra	HMGB2	P26583	COMMD1	Homo sapiens	Q8N668	Y2H	32867128
Intra	HMGB2	P26583	TSNAX	Homo sapiens	Q99598	Validated Y2H	32296183
Intra	HMGB2	P26583	TSNAX	Homo sapiens	Q99598	Y2H Prey Pooling	32296183
Intra	HMGB2	P26583	TSNAX	Homo sapiens	Q99598	Y2H Array	32296183
Intra	HMGB2	P26583	MIEN1	Homo sapiens	Q9BRT3	Y2H	31694235
Intra	HMGB2	P26583	MIEN1	Homo sapiens	Q9BRT3	Anti Bait CoIP	32867128
Intra	HMGB2	P26583	MIEN1	Homo sapiens	Q9BRT3	Y2H	32867128
Intra	HMGB2	P26583	MIEN1	Homo sapiens	Q9BRT3	Y2H	29721183
Intra	HMGB2	P26583	NOP53	Homo sapiens	Q9NZM5	Y2H	31694235
Intra	HMGB2	P26583	NOP53	Homo sapiens	Q9NZM5	Anti Bait CoIP	32867128
Intra	HMGB2	P26583	NOP53	Homo sapiens	Q9NZM5	Y2H	32867128
Intra	HMGB2	P26583	ZNF428	Homo sapiens	Q96B54	Y2H	31694235
Intra	HMGB2	P26583	ZNF428	Homo sapiens	Q96B54	Y2H	32867128
Intra	HMGB2	P26583	ZNF428	Homo sapiens	Q96B54	Y2H	29721183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HMGB2 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P70332	HMGB2/HMG-2 Protein, Human (HEK293, His)	P26583 (G2-E209)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700088AF	Animal-Free HMGB2/HMG-2 Protein, Human (His)	P26583 (M1-E209)	≥ 95%, as determined by reducing SDS-PAGE.

HMGB2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P83250	HMGB2 Antibody (YA2995)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P83250A	HMGB2 Antibody (YA2995)(PBS only)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Juvenile Rheumatoid Arthritis	Juvenile Idiopathic Arthritis Juvenile Chronic Polyarthritis Monarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Arthritis Still'S Disease Systemic Juvenile Rheumatoid Arthritis Juvenile Chronic Arthritis Acute Juvenile Rheumatoid Arthritis Pauciarticular Onset Juvenile Chronic Arthritis Arthritis, Juvenile Rheumatoid Jia Jra Juvenile Ra Arthritis Juvenile Rheumatoid Stills Disease Juvenile Arthritis Acute Polyarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Rheumatoid Arthritis Rheumatoid Arthritis, Systemic Juvenile
Autoimmune Hepatitis	Aih Hepatitis, Autoimmune Autoimmune Chronic Active Hepatitis Autoimmune Hepatitis With Centrilobular Necrosis Autoimmune Chronic Hepatitis Hepatitis Autoimmune

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-113772	Inflachromene	Inhibitor	99.76%	Unkown
HY-P10997	F3 peptide		/	Unkown
HY-RS06233	HMGB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16794	Hmgb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23235	Hmgb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HMGB2	MGD	MGI:96157
Canis familiaris	HMGB2	VGNC	VGNC:41710
Macaca mulatta	HMGB2	VGNC	VGNC:100234
Felis catus	HMGB2	VGNC	VGNC:82520
Rattus norvegicus	HMGB2	RGD	RGD:69291
Others	HMGB2	NCBI