RHOBTB1 - Rho related BTB domain containing 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9886

About RHOBTB1

Cytogenetic location: 10q21.2 Genomic coordinates (GRCh38): 10:60,860,860-61,001,967 (from NCBI)

This gene has 6 transcripts (splice variants), 164 orthologues and 22 paralogues. Broad expression in placenta (RPKM 10.3), kidney (RPKM 7.3) and 22 other tissues.

Summary

The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

RHOBTB1 Products (12)

mRNA Protein Name
NM_001242359.2 NP_001229288.1 rho-related BTB domain-containing protein 1 isoform 1
NM_001350902.2 NP_001337831.1 rho-related BTB domain-containing protein 1 isoform 1
NM_001350903.2 NP_001337832.1 rho-related BTB domain-containing protein 1 isoform 1
NM_001350904.2 NP_001337833.1 rho-related BTB domain-containing protein 1 isoform 1
NM_001350905.2 NP_001337834.1 rho-related BTB domain-containing protein 1 isoform 1
NM_001350906.2 NP_001337835.1 rho-related BTB domain-containing protein 1 isoform 2
NM_001350907.2 NP_001337836.1 rho-related BTB domain-containing protein 1 isoform 2
NM_001350908.2 NP_001337837.1 rho-related BTB domain-containing protein 1 isoform 2
NM_001350909.2 NP_001337838.1 rho-related BTB domain-containing protein 1 isoform 2
NM_001350910.2 NP_001337839.1 rho-related BTB domain-containing protein 1 isoform 2
NM_001350911.2 NP_001337840.1 rho-related BTB domain-containing protein 1 isoform 2
NM_014836.5 NP_055651.1 rho-related BTB domain-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOBTB1 Protein Structure

Ras

Ras: Ras family (16 - 207)

BTB

BTB: BTB/POZ domain (404 - 455)

BTB

BTB: BTB/POZ domain (476 - 581)

  • 0
  • 200
  • 400
  • 600
  • 696 a.a.
Protein Preferred Names Protein Names

rho-related BTB domain-containing protein 1

RHOBTB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RHOBTB1 O94844 PRKCA Homo sapiens P17252
Y2H Array
32814053
Intra
RHOBTB1 O94844 PRKCA Homo sapiens P17252
Validated Y2H
32814053
Intra
RHOBTB1 O94844 PRKCA Homo sapiens P17252
Y2H Pooling
32814053
Intra
RHOBTB1 O94844 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
RHOBTB1 O94844 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
RHOBTB1 O94844 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
RHOBTB1 O94844 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
Intra
RHOBTB1 O94844 KAT5 Homo sapiens Q92993
Y2H Array
32814053
Intra
RHOBTB1 O94844 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
Intra
RHOBTB1 O94844 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
RHOBTB1 O94844 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Intra
RHOBTB1 O94844 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ascaridiasis

  • Ascariasis
Toxic Megacolon

  • Megacolon, Toxic

  • Toxic Dilatation Of Colon

  • Toxic Functional Megacolon
Clostridium Difficile Colitis

  • Pseudomembranous Colitis

  • Colitis Pseudomembranous

  • Enterocolitis, Pseudomembranous

  • Pseudomembranous Enterocolitis

  • Clostridium Difficile Infection
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11947 RHOBTB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RHOBTB1 VGNC VGNC:33945
Rattus norvegicus RHOBTB1 RGD RGD:1306871
Macaca mulatta RHOBTB1 VGNC VGNC:76768
Mus musculus RHOBTB1 MGD MGI:1916538
Canis familiaris RHOBTB1 VGNC VGNC:45556
Felis catus RHOBTB1 VGNC VGNC:64613
Others RHOBTB1 NCBI