α5β1 integrin-IN-1

α5β1 integrin-IN-1 (Compound 65) at 30 μM exhibits only extremely weak inhibitory activity against hERG channels in hERG-expressing cells, with an inhibition rate of 6.11%.
α5β1 integrin-IN-1 (30 μM) does not inhibit hERG ion channel activity at concentrations up to 30 μM.
α5β1 integrin-IN-1 (up to 1000 μg/well) shows no mutagenicity in the Ames test.
α5β1 integrin-IN-1 (10 μM; 5-45 min) does not inhibit the activity of CYP subtypes at a concentration of 10 μM.
α5β1 integrin-IN-1 (pre-incubated at 4°C for 15 min, followed by incubation at 37°C for 1 h) exhibits high α5β1 receptor selectivity in β3-transfected SW480 cells plated on fibrinogen, HT1080 cells plated on rat tail collagen I, SW480 cells plated on vitronectin, and human α4-transfected SW480 cells plated on VCAM-1, with an IC₅₀ of approximately 0.4 nM (pIC₅₀ = 9.4 M).
α5β1 integrin-IN-1 (100 µM) exhibits specific transmembrane permeability and efflux effects in the Caco-2 cell model.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.