GLRX - glutaredoxin Gene

Also Known as GRX; GRX1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2745

About GLRX

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:95,813,849-95,822,726 (from NCBI)

This gene has 7 transcripts (splice variants) and 250 orthologues. Broad expression in kidney (RPKM 54.1), small intestine (RPKM 45.6) and 22 other tissues.

Summary

This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]

GLRX Products (4)

mRNA	Protein	Name
NM_001118890.2	NP_001112362.1	glutaredoxin-1
NM_001243658.2	NP_001230587.1	glutaredoxin-1
NM_001243659.2	NP_001230588.1	glutaredoxin-1
NM_002064.3	NP_002055.1	glutaredoxin-1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables glutathione disulfide oxidoreductase activity	EXP EXP: Inferred from Experiment	7851394	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16884690	GOA
enables sodium channel regulator activity	IDA IDA: Inferred from direct assay	19542013	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of membrane potential	IDA IDA: Inferred from direct assay	19542013	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLRX Protein Structure

Glutaredoxin

0
100
106 a.a.

Protein Preferred Names	Protein Names
glutaredoxin-1	TTase-1

GLRX Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GLRX	P35754	TRIM62	Homo sapiens	Q9BVG3	Validated Y2H	32296183
Intra	GLRX	P35754	TRIM62	Homo sapiens	Q9BVG3	Y2H Array	32296183
Intra	GLRX	P35754	TRIM62	Homo sapiens	Q9BVG3	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GLRX Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76366	GRX1/Glutaredoxin 1 Protein, Human (His)	P35754 (M1-Q106)	≥ 95%, as determined by reducing SDS-PAGE.

GLRX Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811248	Glutaredoxin Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 25	DFNB25 Autosomal Recessive Nonsyndromic Deafness 25 Autosomal Recessive Deafness 25 Deafness, Autosomal Recessive, 25 Deafness, Autosomal Recessive, Type 25
Pancreatic Cystadenocarcinoma	Cystadenocarcinoma Of Pancreas
Non-Syndromic X-Linked Intellectual Disability 1	Mrx1 Mrx18 Mrx78 X-Linked Mental Retardation 1/78 X-Linked Mental Retardation 18
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Cortical Dysplasia, Complex, With Other Brain Malformations 6	Complex Cortical Dysplasia With Other Brain Malformations 6 CDCBM6 Cdcbm56 Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125848	Ginsenoside F2		99.92%	Unkown
HY-RS05499	GLRX5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05497	GLRX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05496	GLRX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05498	GLRX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18939	Glrx Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22529	Glrx5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25429	Glrx Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29049	Glrx5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GLRX	VGNC	VGNC:41273
Mus musculus	GLRX	MGD	MGI:2135625
Macaca mulatta	GLRX	VGNC	VGNC:84383
Rattus norvegicus	GLRX	RGD	RGD:70951
Others	GLRX	NCBI