NKTR - natural killer cell triggering receptor Gene
Also Known as p104
Species: Homo sapiens
About NKTR
This gene has 18 transcripts (splice variants), 201 orthologues and 22 paralogues. Ubiquitous expression in bone marrow (RPKM 22.3), skin (RPKM 14.4) and 25 other tissues.
Summary
This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008]
NKTR Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001349124.2 | NP_001336053.1 | NK-tumor recognition protein isoform c |
| NM_001349125.2 | NP_001336054.1 | NK-tumor recognition protein isoform d |
| NM_001349126.2 | NP_001336055.1 | NK-tumor recognition protein isoform e |
| NM_005385.4 | NP_005376.2 | NK-tumor recognition protein isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables peptidyl-prolyl cis-trans isomerase activity |
IDA
IDA: Inferred from direct assay
|
20676357 | GOA |
NKTR Protein Structure
Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (11 - 175)
- 0
- 300
- 600
- 900
- 1200
- 1462 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
NK-tumor recognition protein |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Theileriasis |
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| Opioid Abuse |
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| Noonan Syndrome 1 |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | NKTR | VGNC | VGNC:32097 |
| Macaca mulatta | NKTR | VGNC | VGNC:81486 |
| Rattus norvegicus | NKTR | RGD | RGD:2321593 |
| Felis catus | NKTR | VGNC | VGNC:97529 |
| Canis familiaris | NKTR | VGNC | VGNC:56102 |
| Mus musculus | NKTR | MGD | MGI:97346 |
| Others | NKTR | NCBI |