Anticancer agent 315
Anticancer agent 315 is an antitumor agent. Anticancer agent 315 binds to the active pocket of thymidylate synthase via forming strong hydrogen bonds with Lys487 and Ala498, stabilizing the arrangement of the ligand within the pocket. Anticancer agent 315 inhibits the proliferation of tumor cells. Anticancer agent 315 can be used for the research of liver cancer and breast cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C23H17N11O3S
- 分子量:527.52
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
Anticancer agent 315 (compound 23) potently inhibits the viability of HepG2 and MCF-7 cancer cells, while exhibiting low toxicity toward WI-38 and VERO normal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HepG2 and MCF-7 cancer cells, WI-38 and VERO normal cells
-
Concentration:/
-
Incubation Time:/
-
Result:Had IC50 values of 15.9 µM and 18.0 µM for HepG2 and MCF-7 cancer cells.
Had IC50 values of 40.2 µM and 45.7 µM for WI-38 and VERO normal cells.
化学情報
-
分子量 527.52
-
分子式 C23H17N11O3S
-
SMILES
O=C(C1=C(N/N=C(C#N)/C#N)NN=C1NC2=CC=CC=C2)NC3=CC=C(S(=O)(NC4=NC=CC=N4)=O)C=C3
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anticancer agent 315 関連分類
HY-183108 関連分類
Powered by Bioz