Antitrypanosomal agent 28
Antitrypanosomal agent 28 (Compound 2a) is a trypanocidal agent. Antitrypanosomal agent 28 effectively inhibits Trypanosoma cruzi by inducing the generation of ROS and mitochondrial damage, with an IC₅₀ of 49.4 μM. Antitrypanosomal agent 28 exhibits broad-spectrum anti-tumor activity against various tumor cell lines, especially being sensitive to leukemia, colon cancer, and breast cancer. Antitrypanosomal agent 28 can be used for research on anti-cancer and anti-trypanosome activities.
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- CAS 番号: 2413738-47-1
- 分子式: C27H21NO
- 分子量:375.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
化学情報
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CAS 番号 2413738-47-1
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分子量 375.46
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分子式 C27H21NO
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SMILES
CC1=NC2=CC=CC=C2C(/C=C/C3=CC=CC=C3)=C1C(/C=C/C4=CC=CC=C4)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Rodríguez D, et al. Quinolinyl-appended chalcones as promising antiproliferative and trypanocidal agents: Synthesis, biological profiling, and further transformation into novel benzo[f]pyrazolo[5,1-a][2,7]naphthyridine and quinoline-pyrido[2,3-d]pyrimidin-2,4-dione hybrids. Bioorg Chem. 2025 Dec 2;168:109306. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antitrypanosomal agent 28 関連分類
HY-180158 関連分類
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- Antitrypanosomal agent 28
- 2413738-47-1
- Antitrypanosomal agent28
- Antitrypanosomal agent-28
- Parasite
- Reactive Oxygen Species (ROS)
- Quinolinyl-chalcones
- antiproliferative agents
- trypanocidal activity
- oxidative stress
- mitochondrial membrane potential
- NCI-60 screening
- structure-activity relationship
- Inhibitor
- inhibitor
- inhibit