2413738-47-1
Chemical Structure
Antitrypanosomal agent 28
- CAS No.: 2413738-47-1
- Formula:C27H21NO
- Molecular Weight:375.46
InChIKey: QFRYTLSPRIQUOO-YWNVXTCZSA-N
SMILES: CC1=NC2=CC=CC=C2C(/C=C/C3=CC=CC=C3)=C1C(/C=C/C4=CC=CC=C4)=O
Biological Activity: Antitrypanosomal agent 28 (Compound 2a) is a trypanocidal agent. Antitrypanosomal agent 28 effectively inhibits Trypanosoma cruzi by inducing the generation of ROS and mitochondrial damage, with an IC₅₀ of 49.4 μM. Antitrypanosomal agent 28 exhibits broad-spectrum anti-tumor activity against various tumor cell lines, especially being sensitive to leukemia, colon cancer, and breast cancer. Antitrypanosomal agent 28 can be used for research on anti-cancer and anti-trypanosome activities[1].
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Antitrypanosomal agent 28 | Antitrypanosomal agent 28 (Compound 2a) is a trypanocidal agent. Antitrypanosomal agent 28 effectively inhibits Trypanosoma cruzi by inducing the generation of ROS and mitochondrial damage, with an IC₅₀ of 49.4 μM. Antitrypanosomal agent 28 exhibits broad-spectrum anti-tumor activity against various tumor cell lines, especially being sensitive to leukemia, colon cancer, and breast cancer. Antitrypanosomal agent 28 can be used for research on anti-cancer and anti-trypanosome activities. | |||||||||||||||||||||
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- [1]. Rodríguez D, et al. Quinolinyl-appended chalcones as promising antiproliferative and trypanocidal agents: Synthesis, biological profiling, and further transformation into novel benzo[f]pyrazolo[5,1-a][2,7]naphthyridine and quinoline-pyrido[2,3-d]pyrimidin-2,4-dione hybrids. Bioorg Chem. 2025 Dec 2;168:109306. [Content Brief]
Keywords
