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製品番号: HY-114721

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BTA-9881

Name: BTA-9881
Brand: MedChemExpress
SKU: HY-114721
Price: 192.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(別名: MEDI-564)

BTA-9881 (MEDI-564) is a RSV inhibitor, with an EC₅₀: 48 nM, 59 nM and 160 nM for RSV A2, RSV Long, and RSV B1. BTA-9881 has favorable pharmacokinetics property.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1646857-24-0
分子式: C₂₁H₁₅ClN₄O₂
分子量:390.82

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

BTA-9881 構造式

CAS 番号: 1646857-24-0

容量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

BTA-9881 (MEDI-564) is a RSV inhibitor, with an EC₅₀: 48 nM, 59 nM and 160 nM for RSV A2, RSV Long, and RSV B1. BTA-9881 has favorable pharmacokinetics property^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEp-2	EC₅₀	0.048 μM Compound: 33a	Antiviral activity against respiratory syncytial virus A2 infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against respiratory syncytial virus A2 infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 25595685]
HEp-2	EC₅₀	0.059 μM Compound: 33a	Antiviral activity against respiratory syncytial virus Long infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against respiratory syncytial virus Long infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 25595685]
HEp-2	EC₅₀	0.16 μM Compound: 33a	Antiviral activity against respiratory syncytial virus B1 infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against respiratory syncytial virus B1 infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 25595685]

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 1646857-24-0
分子量 390.82
分子式 C₂₁H₁₅ClN₄O₂
SMILES

O=C1N2[C@@](C3=CC=C(C=C3)Cl)(N(CC2)C(C4=CC=CN=C4)=O)C5=C1C=CN=C5
別名

MEDI-564
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Bond S, et al. 1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: identification of BTA9881 as a preclinical candidate. Bioorg Med Chem Lett. 2015 Feb 15;25(4):976-81. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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