Carumonam
Carumonam (AMA-1080; Ro 17-2301) is a sulfonated monocyclic β-Lactam Antibiotic, targeting to penicillin-binding protein (PBP). Carumonam exerts highly activity against Enterobacteriaceae, Pseudomonas aeruginosa, and Haemophilus influenzae, while it weakly and even inactively inhibits Streptococcus pneumoniae and Staphylococcus aureus. Carumonam is resistant to beta-lactamase-mediated hydrolysis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 87638-04-8
- 分子式: C12H14N6O10S2
- 分子量:466.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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β-lactam |
Carumonam shows inhibition against Enterobacteriaceae isolates with MIC90 values of 0.013-25 μg/mL, while it inhibits P. aeruginosa with a MIC90 value of 12.5 μg/mL[1].
Carumonam (0-400 μg/mL) has high affinity to binding PBP-3 in Enterobacteriaceae and P. aeruginosa with IC50s as same with or smaller than the MICs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Animal: Five-week-old male Slc:ICR mice (20-25 g), 7-week-old male Jcl:SD rats (210-250 g), male New Zealand White rabbits (2.5-3.5 kg), male and female beagle dogs (10-15 kg), and female cynomolgus monkeys (2.8-3.7 kg). They are deprived of feed for 16 to 18 h before the antibiotic was administered; water was given ad libitum[2].
Pharmacokinetic Analysis[2]
| Animal | Dose (mg/kg) | Route | Tmax (h) | Cmax (μg/mL) | AUC (μg·h/mL) | t1/2 (h) | CLp (mL/min/kg) |
| Mouse | 2 mg/mL, 0.1 mL/10 g | s.c. | 0.12 | 40.7 | 20.0 | 0.24 | 16.7 |
| Rat | 10 mg/mL, 0.2 mL/100 g | i.m. | 0.18 | 37.9 | 23.9 | 0.28 | 14.0 |
| Rabbit | 40 mg/mL, 0.5 mL/kg | i.m. | 0.36 | 44.9 | 66.6 | 0.73 | 5.0 |
| Dog | 100 mg/mL, 0.2 mL/kg | i.m. | 0.36 | 36.3 | 61.1 | 1.10 | 5.5 |
| Monkey | 20 mg/mL/kg | i.m. | 0.29 | 67.9 | 80.4 | 0.89 | 4.5 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 87638-04-8
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分子量 466.40
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分子式 C12H14N6O10S2
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SMILES
O=C(CO/N=C(C(N[C@H]1[C@H](N(C1=O)S(=O)(O)=O)COC(N)=O)=O)/C2=CSC(N)=N2)O
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別名
AMA-1080; Ro 17-2301
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Imada A, et al. In vitro and in vivo antibacterial activities of carumonam (AMA-1080), a new N-sulfonated monocyclic beta-lactam antibiotic. Antimicrob Agents Chemother. 1985 May;27(5):821-7. [Content Brief]
[2]. Kita Y, et al. Comparative pharmacokinetics of carumonam and aztreonam in mice, rats, rabbits, dogs, and cynomolgus monkeys. Antimicrob Agents Chemother. 1986 Jan;29(1):127-34. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Carumonam 関連分類
HY-121329 関連分類
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