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製品番号: HY-156074

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Erythromycin propionate

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Erythromycin propionate, erythromycin (HY-B0220) derivative, is a macrolide antibiotic used in the treatment of a wide variety of bacterial infections. Erythromycin propionate causes several cases of liver injury which mostly include cholestatic hepatitis. Erythromycin propionate toxicity is related to its inhibitory effect on bile acid transport.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 134-36-1
分子式: C₄₀H₇₁NO₁₄
分子量:789.99

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

Erythromycin propionate 構造式

CAS 番号: 134-36-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Erythromycin propionate, erythromycin (HY-B0220) derivative^[1], is a macrolide antibiotic used in the treatment of a wide variety of bacterial infections. Erythromycin propionate causes several cases of liver injury which mostly include cholestatic hepatitis. Erythromycin propionate toxicity is related to its inhibitory effect on bile acid transport^[2].

Antibiotic アイソフォーム固有の製品をすべて表示 :

Aminotransferases (Transaminases) アイソフォーム固有の製品をすべて表示 :

体外実験

Erythromycin propionate inactivates viral particles by destroying the integrity of the viral membrane, resulting in the release of viral genomic RNA, and the irreversible loss of infection ability. Erythromycin propionate inhibits various flaviviruses, including Zika virus (ZIKV), dengue virus (DENV), yellow fever virus (YFV) and human coronavirus OC43 (HCoV-OC43)^[2].
Erythromycin propionate (2.5-10 µM, 48 h) reduces the virus titer of HCoV-OC43 with an IC₅₀ of 1.40 µM, reduces the number of HCoV-OC43 infected BHK-21 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[2]

Cell Line:

BHK-21
Concentration:

2.5-10 µM
Incubation Time:

48 h
Result:

Reduced the viral nucleoprotein.

体内実験

Erythromycin propionate (450-1200 mg/kg, po, once daily for 7 days) activates alanine aminotransferase (ALT), induces oxidative stress, and exhibits hepatotoxicity in Wistar rats models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats models^[1]
Dosage:

450-1200 mg/kg
Administration:

po, once daily for 7 days
Result:

Caused hydropic degeneration of hepatocytes.
Increased serum bilirubin (TBILI) levels and alanine aminotransferase (ALT) activity.
Decreased serum triglyceride (TG) levels and glutathione (GSH) content in liver tissue.

化学情報

CAS 番号 134-36-1
分子量 789.99
分子式 C₄₀H₇₁NO₁₄
SMILES

CCC(O[C@H]([C@H](C[C@H](O1)C)N(C)C)[C@@H]1O[C@@H]2[C@H]([C@@H]([C@H](C(O[C@@H]([C@@](O)([C@@H]([C@H](C([C@@H](C[C@]2(O)C)C)=O)C)O)C)CC)=O)C)O[C@H]3C[C@](C)([C@H]([C@@H](O3)C)O)OC)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Viruses

Erythromycin Estolate Inhibits Zika Virus Infection by Blocking Viral Entry as a Viral Inactivator. [Abstract]

2019 Nov 15;11(11):1064. PMID: 31731598

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (280 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zimmerman HJ, et al. Studies on the vitro cytotoxicity of erythromycin estolate. Proc Soc Exp Biol Med. 1973 Dec;144(3):759-61. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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Erythromycin propionate

1 Cited Publications

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Publications (1)
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Erythromycin propionate

MedChemExpress（MCE）の使用を引用している文献 Erythromycin propionate

Antibiotic アイソフォーム固有の製品をすべて表示

Aminotransferases (Transaminases) アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Erythromycin propionate 関連分類

HY-156074 関連分類