Klb - klotho beta Gene

Also Known as betaKlotho

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 83379

Summary

Predicted to enable Fibroblast Growth Factor binding activity and Fibroblast Growth Factor receptor binding activity. Acts upstream of or within positive regulation of MAPKKK cascade by Fibroblast Growth Factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be integral component of membrane. Is expressed in several structures, including extraembryonic component; gut; liver; lung; and trunk mesenchyme. Orthologous to human KLB (klotho beta). [provided by Alliance of Genome Resources, Apr 2022]

Klb Products (1)

mRNA Protein Name
NM_031180.2 NP_112457.1 beta-klotho

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
17452648 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
18187602 MGI
acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
18187602 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
18187602 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-klotho

  • BKL

  • klotho beta-like protein

Klb Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
Klb Q99N32 Fgfr4 Mus musculus Q03142
Anti Tag CoIP
17452648
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Klb Proteins

製品番号 製品名 アクセッション番号 純度
HY-P78714 Klotho beta Protein, Mouse (HEK293, His) Q99N32 (F53-L995) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS18451 Klb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07325 KLB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24932 Klb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Klb NCBI NCBI:152831