Klb - klotho beta Gene

Also Known as betaKlotho

Species: Mus musculus

Gene Type: protein coding
Gene ID: 83379

Summary

Predicted to enable Fibroblast Growth Factor binding activity and Fibroblast Growth Factor receptor binding activity. Acts upstream of or within positive regulation of MAPKKK cascade by Fibroblast Growth Factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be integral component of membrane. Is expressed in several structures, including extraembryonic component; gut; liver; lung; and trunk mesenchyme. Orthologous to human KLB (klotho beta). [provided by Alliance of Genome Resources, Apr 2022]

Klb Products (1)

mRNA Protein Name
NM_031180.2 NP_112457.1 beta-klotho

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17452648 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
18187602 MGI
acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
18187602 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
18187602 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-klotho

  • BKL

  • klotho beta-like protein

Klb Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Klb Q99N32 Fgfr4 Mus musculus Q03142
Anti Tag CoIP
17452648
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Klb Proteins

Cat. No. Product Name Accession Purity
HY-P78714 Klotho beta Protein, Mouse (HEK293, His) Q99N32 (F53-L995) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18451 Klb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07325 KLB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24932 Klb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Klb NCBI NCBI:152831