KLB - klotho beta Gene

Also Known as BKL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 152831

About KLB

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:39,406,930-39,451,533 (from NCBI)

This gene has 1 transcript (splice variant), 202 orthologues and 4 paralogues. Biased expression in fat (RPKM 16.3), liver (RPKM 5.1) and 2 other tissues.

Summary

Enables Fibroblast Growth Factor binding activity and Fibroblast Growth Factor receptor binding activity. Predicted to be involved in Fibroblast Growth Factor receptor signaling pathway. Predicted to act upstream of or within positive regulation of MAPKKK cascade by Fibroblast Growth Factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

KLB Products (1)

mRNA Protein Name
NM_175737.4 NP_783864.1 beta-klotho

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables fibroblast growth factor binding IPI
IPI: Inferred from physical interaction
18829467 GOA
enables fibroblast growth factor receptor binding IPI
IPI: Inferred from physical interaction
17627937 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19059246 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLB Protein Structure

Glyco_hydro_1

Glyco_hydro_1: Glycosyl hydrolase family 1 (79 - 373)

Glyco_hydro_1

Glyco_hydro_1: Glycosyl hydrolase family 1 (390 - 508)

Glyco_hydro_1

Glyco_hydro_1: Glycosyl hydrolase family 1 (519 - 966)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1044 a.a.
Protein Preferred Names Protein Names

beta-klotho

  • b-Klotho

KLB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLB Q86Z14 FGF21 Homo sapiens Q9NSA1
SPR
19059246
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KLB Proteins

Cat. No. Product Name Accession Purity
HY-P77972 Klotho beta Protein, Human (HEK293, His) Q86Z14 (M30-T983) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Functional Diarrhea

  • Functional Diarrhoea
Outlet Dysfunction Constipation
Epilepsy, Idiopathic Generalized 4

  • EIG4

  • Epilepsy, Idiopathic Generalized, Susceptibility To 4

  • Idiopathic Generalized Epilepsy 4

  • Epilepsy, Idiopathic Generalized, Susceptibility To, 4

  • Epilepsy, Idiopathic Generalized Locus On Chromosome 10

  • Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 10
Hypogonadotropic Hypogonadism 23 With Or Without Anosmia

  • Fertile Eunuch Syndrome

  • Pasqualini Syndrome

  • HH23

  • 46,Xy Disorder Of Sex Development Due To Lhb Deficiency

  • 46,Xy Disorder Of Sex Development Due To Luteinizing Hormone Subunit Beta Deficiency

  • 46,Xy Dsd Due To Lhb Deficiency

  • 46,Xy Dsd Due To Luteinizing Hormone Subunit Beta Deficiency

  • Leydig Cell Hypoplasia Due To Lhb Deficiency

  • Leydig Cell Hypoplasia Due To Luteinizing Hormone Subunit Beta Deficiency

  • Eunuchoidism With Spermatogenesis, Normal Fsh And Low Or Normal Interstitial Cell-Stimulating Hormone

  • Hypogonadism, Hypogonadotropic, Type 23, With/Without Anosmia
Non-Alcoholic Fatty Liver Disease

  • Fatty Liver

  • Non-Alcoholic Fatty Liver

  • Nafld

  • Nonalcoholic Fatty Liver Disease

  • Nonalcoholic Steatohepatitis

  • Steatosis

  • Nafl

  • Nash

  • Non-Alcoholic Steatohepatitis

  • Susceptibility To Nonalcoholic Fatty Liver Disease

  • Steatohepatitis

  • Fatty Degeneration

  • Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

  • Nafld Without Nash

  • Nafld Without Mention Of Nash
Diarrhea

  • Diarrhoea

  • Diarrhea Of Presumed Infectious Origin
Tick-Borne Encephalitis

  • Siberian Tick-Borne Encephalitis

  • Encephalitis, Tick-Borne

  • Central European Encephalitis

  • Far Eastern Tbe

  • Russian Spring-Summer Encephalitis

  • Taiga Encephalitis

  • West-Siberian Encephalitis

  • Western European Tick-Borne Encephalitis

  • Tbe

  • Encephalitis Tick-Borne

  • Encephalitis, Central European

  • Encephalitis, Far Eastern Russian
Intrahepatic Cholestasis Of Pregnancy

  • Recurrent Intrahepatic Cholestasis Of Pregnancy

  • Gravidic Intrahepatic Cholestasis

  • Pregnancy-Related Cholestasis

  • Icp

  • Pregnancy Related Cholestasis

  • Cholestasis, Intrahepatic Of Pregnancy

  • Familial Intrahepatic Cholestasis Of Pregnancy

  • Familial Recurrent Intrahepatic Cholestasis Of Pregnancy

  • Ricp

  • Obstetric Cholestasis
Adult Hepatocellular Carcinoma

  • Adult Primary Hepatocellular Carcinoma

  • Adult Hepatoma

  • Adult Hcc
Kallmann Syndrome

  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia
Primary Biliary Cholangitis

  • Primary Biliary Cirrhosis

  • Biliary Liver Cirrhosis

  • Chronic Nonsuppurative Destructive Cholangitis

  • Familial Primary Biliary Cirrhosis

  • Pbc

  • Hanot Syndrome

  • Cholestatic Cirrhosis

  • Biliary Cirrhosis Primary

  • Liver Cirrhosis, Biliary

  • Hanot'S Cirrhosis

  • Biliary Cirrhosis

  • Pericholangiolic Biliary Cirrhosis

  • Tannhauser-Magendantz Syndrome

  • Hanot-Rossle Syndrome

  • Hypertrophic Cirrhosis

  • Todd Cirrhosis

  • Hanot Cirrhosis

  • Charcot Cirrhosis

  • Mahon-Tannhauser Syndrome

  • Toxic Cirrhosis

  • Hypertrophic Biliary Cirrhosis

  • Monolobular Cirrhosis

  • Unilobar Cirrhosis

  • Xanthomatous Biliary Cirrhosis
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18451 Klb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07325 KLB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24932 Klb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KLB VGNC VGNC:73835
Felis catus KLB VGNC VGNC:63126
Bos taurus KLB VGNC VGNC:30622
Canis familiaris KLB VGNC VGNC:42426
Mus musculus KLB MGD MGI:1932466
Rattus norvegicus KLB RGD RGD:1308227
Others KLB NCBI