GPLGIAGQC
GPLGIAGQC is an MMP2-cleavable peptide. In nanoparticle-drug conjugation systems, GPLGIAGQC is cleaved by MMP2 between the glycine and isoleucine residues. After MMP2-mediated hydrolysis of GPLGIAGQC, the Fc fragment is exposed on the surface of nanoparticles.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1423719-70-3
- 分子式: C34H58N10O11S
- 分子量:814.95
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
The GPLGIAGQC peptide (10-40 nM MMP2; 24 h) acts as an MMP2-cleavable linker in AP-PP-DOX nanoparticles, enabling sustained, MMP2-dependent release of DOX with minimal leakage in MMP2-deficient conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1423719-70-3
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分子量 814.95
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分子式 C34H58N10O11S
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配列
Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln-Cys
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シーケンスの短縮
GPLGIAGQC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Wang MZ, et al. A Nano Drug Delivery System Based on Angelica sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy. Molecules. 2020 Jul 7;25(13):3096. [Content Brief]
[2]. Liu XY, et al. A nano-innate immune system activator for cancer therapy in a 4T1 tumor-bearing mouse model. J Nanobiotechnology. 2022 Jan 29;20(1):54. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GPLGIAGQC 関連分類
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