HDAC6-IN-85
Based on 1 Customer Validation
HDAC6-IN-85 is a selective HDAC6 inhibitor, with pIC50 values of 5.4, 5.5, 5.9, and 4.8 against rHDAC1, rHDAC3, rHDAC6, and rHDAC8, respectively. HDAC6-IN-85 can be used in the research of cervical cancer, lung cancer, and colon cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 948837-73-8
- 分子式: C12H14O2S3
- 分子量:286.43
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
生物活性
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HDAC1 5.4 (pIC50) |
HDAC3 5.5 (pIC50) |
HDAC6 5.9 (pIC50) |
HDAC8 4.8 (pIC50) |
HDAC6-IN-85 (Compound 7) potently inhibits the HDAC isozyme mixture in HeLa nuclear extracts, with a pIC50 of 6.3[1].
HDAC6-IN-85 inhibits the proliferation of HeLa cervical cancer cells with a pIC50 value of 5.6[1].
HDAC6-IN-85 inhibits recombinant HDAC isozymes, with the highest inhibitory potency against rHDAC6 (pIC50 = 5.9) and the lowest inhibitory potency against rHDAC8 (pIC50 = 4.8)[1].
HDAC6-IN-85 inhibits the proliferation of A549 lung cancer cells and RKO colon cancer cells, with a pIC50 value of 5.2 for the former and 5.7 for the latter[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 948837-73-8
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性状 Solid
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分子量 286.43
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分子式 C12H14O2S3
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Color Light yellow to yellow
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SMILES
O=C(CSC(SCC)=S)C1=CC=C(C=C1)OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)