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製品番号: HY-W490804

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HPTE

HPTE is the active in vivo metabolite of Methoxychlor (HY-B1873), and acts as an inhibitor of 3β‑HSD and 17β‑HSD3. HPTE binds to the substrate-binding pocket of 3β‑HSD in a non-competitive manner, but competitively occupies the coenzyme NAD⁺-binding site, thereby inhibiting the conversion of pregnenolone to progesterone. HPTE binds to the androstenedione-binding pocket (the substrate pocket) of 17β‑HSD3 in a non-competitive manner, and competitively occupies the coenzyme NADPH-binding site, thus blocking the conversion of androstenedione to testosterone. HPTE interferes with androgen biosynthesis in Leydig cells by inhibiting the activities of these two key steroidogenic enzymes. HPTE can be used in studies related to androgen biosynthesis.

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CAS 番号: 2971-36-0
分子式: C₁₄H₁₁Cl₃O₂
分子量:317.59

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

HPTE 構造式

CAS 番号: 2971-36-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

^[1]

17β-HSD5

3β-HSD アイソフォーム固有の製品をすべて表示 :

3β-HSD I

17β-HSD アイソフォーム固有の製品をすべて表示 :

17β-HSD5/AKR1C3

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	30.7 nM Compound: BPE-Cl; HPTE	Agonist activity at ERalpha (unknown origin) expressed in human HeLa cells assessed as transcriptional activation measured after 24 hrs by luciferase reporter gene assay Agonist activity at ERalpha (unknown origin) expressed in human HeLa cells assessed as transcriptional activation measured after 24 hrs by luciferase reporter gene assay	[PMID: 31879182]
HeLa	IC₅₀	85.4 nM Compound: BPE-Cl; HPTE	Antagonist activity at ERbeta (unknown origin) expressed in human HeLa cells assessed as inhibition of E2-induced transcriptional activity measured after 24 hrs by luciferase reporter gene assay based Schild plot analysis Antagonist activity at ERbeta (unknown origin) expressed in human HeLa cells assessed as inhibition of E2-induced transcriptional activity measured after 24 hrs by luciferase reporter gene assay based Schild plot analysis	[PMID: 31879182]

体外実験

HPTE inhibits the activity of human testicular microsomal 3β-HSD with an IC₅₀ of 8.29 μM, and inhibits the activity of rat testicular microsomal 3β-HSD with an IC₅₀ of 13.82 μM. It acts as a non-competitive inhibitor of the substrate PREG and a competitive inhibitor of the cofactor NAD⁺^[1].
HPTE inhibits the activity of human testicular microsomal 17β-HSD3 with an IC₅₀ of 12.12 μM, and inhibits the activity of rat testicular microsomal 17β-HSD3 with an IC₅₀ of 32.0 μM. It acts as a non-competitive inhibitor of the substrate DIONE and a competitive inhibitor of the cofactor NADPH^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2971-36-0
性状 Solid
分子量 317.59
分子式 C₁₄H₁₁Cl₃O₂
SMILES

ClC(Cl)(C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)O)Cl
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Hu GX, et al. Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase-3 activities in human and rat testes. International journal of andrology. 2011 Apr;34(2):138-44.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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HPTE

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